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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | López-Sánchez, Laura M. López-Pedrera, Chary Rodríguez-Ariza, Antonio |
| Description | Country affiliation: Spain Author Affiliation: López-Sánchez LM ( Research Unit, Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Hospital Reina Sofía, Universidad de Córdoba, Spain.) |
| Abstract | Many of nitric oxide (NO) actions are mediated through the coupling of a nitroso moiety to a reactive cysteine leading to the formation of a S-nitrosothiol (SNO), a process known as S-nitrosylation or S-nitrosation. In many cases this reversible post-translational modification is accompanied by altered protein function and aberrant S-nitrosylation of proteins, caused by altered production of NO and/or impaired SNO homeostasis, has been repeatedly reported in a variety of pathophysiological settings. A growing number of studies are directed to the identification and characterization of those proteins that undergo S-nitrosylation and the analysis of S-nitrosoproteomes under pathological conditions is beginning to be reported. The study of these S-nitrosoproteomes has been fueled by advances in proteomic technologies that are providing researchers with improved tools for exploring this post-translational modification. Here we review novel refinements and improvements to these methods, and some recent studies of the S-nitrosoproteome in disease. |
| File Format | HTM / HTML |
| ISSN | 02777037 |
| Issue Number | 1 |
| Volume Number | 33 |
| e-ISSN | 10982787 |
| Journal | Mass Spectrometry Reviews |
| Language | English |
| Publisher | Wiley |
| Publisher Date | 2014-01-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Analytical Discipline Chemistry Techniques Proteins Chemistry Proteomics Methods S-nitrosothiols Analysis Animals Cysteine Metabolism Humans Nitric Oxide Nitrosation Protein Processing, Post-translational Journal Article Research Support, Non-u.s. Gov't Review |
| Content Type | Text |
| Resource Type | Article |
| Subject | Spectroscopy Analytical Chemistry Biochemistry, Genetics and Molecular Biology Condensed Matter Physics |
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