NDLI: (31)P CSI of the human brain in healthy subjects and tumor patients at 9.4 T with a three-layered multi-nuclear coil: initial results.

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(31)P CSI of the human brain in healthy subjects and tumor patients at 9.4 T with a three-layered multi-nuclear coil: initial results.

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(31)P CSI of the human brain in healthy subjects and tumor patients at 9.4 T with a three-layered multi-nuclear coil: initial results.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Mirkes, Christian Shajan, Gunamony Chadzynski, Grzegorz Buckenmaier, Kai Bender, Benjamin Scheffler, Klaus
Description	Country affiliation: Germany Author Affiliation: Mirkes C ( Department for Biomedical Magnetic Resonance, University of Tübingen, Tübingen, Germany. christian.mirkes@tuebingen.mpg.de.); Shajan G ( High-Field MR Center, Max Planck Institute for Biological Cybernetics, Spemannstr. 41, 72076, Tübingen, Germany. christian.mirkes@tuebingen.mpg.de.); Chadzynski G ( High-Field MR Center, Max Planck Institute for Biological Cybernetics, Spemannstr. 41, 72076, Tübingen, Germany.); Buckenmaier K ( Department for Biomedical Magnetic Resonance, University of Tübingen, Tübingen, Germany.); Bender B ( High-Field MR Center, Max Planck Institute for Biological Cybernetics, Spemannstr. 41, 72076, Tübingen, Germany.); Scheffler K ( High-Field MR Center, Max Planck Institute for Biological Cybernetics, Spemannstr. 41, 72076, Tübingen, Germany.)
Abstract	OBJECTIVE: Investigation of the feasibility and performance of phosphorus ((31)P) magnetic resonance spectroscopic imaging (MRSI) at 9.4 T with a three-layered phosphorus/proton coil in human normal brain tissue and tumor. MATERIALS AND METHODS: A multi-channel (31)P coil was designed to enable MRSI of the entire human brain. The performance of the coil was evaluated by means of electromagnetic field simulations and actual measurements. A 3D chemical shift imaging approach with a variable repetition time and flip angle was used to increase the achievable signal-to-noise ratio of the acquired (31)P spectra. The impact of the resulting k-space modulation was investigated by simulations. Three tumor patients and three healthy volunteers were scanned and differences between spectra from healthy and cancerous tissue were evaluated qualitatively. RESULTS: The high sensitivity provided by the 27-channel (31)P coil allowed acquiring CSI data in 22 min with a nominal voxel size of 15 × 15 × 15 mm(3). Shimming and anatomical localization could be performed with the integrated four-channel proton dipole array. The amplitudes of the phosphodiesters and phosphoethanolamine appeared reduced in tumorous tissue for all three patients. A neutral or slightly alkaline pH was measured within the brain lesions. CONCLUSION: These initial results demonstrate that (31)P 3D CSI is feasible at 9.4 T and could be performed successfully in healthy subjects and tumor patients in under 30 min.
File Format	HTM / HTML
ISSN	09685243
Issue Number	3
Journal	Magnetic Resonance Materials in Physics, Biology and Medicine
Volume Number	29
e-ISSN	13528661
Language	English
Publisher	Springer
Publisher Date	2016-06-01
Publisher Place	Germany
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Diagnostic Imaging
Content Type	Text
Resource Type	Article
Subject	Radiology, Nuclear Medicine and Imaging Biophysics Radiological and Ultrasound Technology

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