NDLI: Prolonged treatment with the anabolic–androgenic steroid stanozolol increases antioxidant defences in rat skeletal muscle

Please wait, while we are loading the content...

Year: 2017 Volume: 73

Year: 2016 Volume: 72

Year: 2015 Volume: 71

Year: 2014 Volume: 70

Year: 2013 Volume: 69

Year: 2012 Volume: 68

Year: 2011 Volume: 67

Year: 2010 Volume: 66

Year: 2010 Volume: 66 Issue: 4

Year: 2010 Volume: 66 Issue: 3

Year: 2010 Volume: 66 Issue: 2

Year: 2010 Volume: 66 Issue: 1

Modulatory effect of N-acetylcysteine on pro-antioxidant status and haematological response in healthy men.

RARgamma and TRbeta expressions are decreased in PBMC and SWAT of obese subjects in weight gain.

Cot/Tpl2 regulates IL-23 p19 expression in LPS-stimulated macrophages through ERK activation.

Soluble HLA-G induces NF-kappaB activation in natural killer cells.

Hypophysectomy and neurointermediate pituitary lobectomy decrease humoral immune responses to T-independent and T-dependent antigens.

Association of SND1 protein to low density lipid droplets in liver steatosis.

Epidermal growth factor protects the heart against low-flow ischemia-induced injury.

Effects of raloxifene and estradiol on bone turnover parameters in intact and ovariectomized rats.

Immune response to exercise in elite sportsmen during the competitive season.

Nutrient regulation of enteroendocrine cellular activity linked to cholecystokinin gene expression and secretion.

Prolonged treatment with the anabolic–androgenic steroid stanozolol increases antioxidant defences in rat skeletal muscle

Year: 2009 Volume: 65

Prolonged treatment with the anabolic–androgenic steroid stanozolol increases antioxidant defences in rat skeletal muscle

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Delgado, J. Saborido, A. Megías, A.
Description	Country affiliation: Spain Author Affiliation: Delgado J ( Department of Biochemistry and Molecular Biology I, Faculty of Biology, Complutense University, 28040 Madrid, Spain.)
Abstract	Testosterone and its synthetic derivatives anabolic–androgenic steroids have been shown to increase skeletal muscle work capacity and fatigue resistance, but the molecular basis for these effects remains uncertain. Since muscle performance has been related to redox status of exercising muscles, this investigation was aimed at testing whether a treatment with suprapharmacological doses of the anabolic–androgenic steroid stanozolol, (2 mg/kg body weight, 5 days/week, for 8 weeks), either alone or in conjunction with treadmill training (12 weeks), enhanced antioxidant defences in rat muscles. Stanozolol treatment did not modify thiobarbituric acid reactive substances and glutathione content in soleus and extensor digitorum longus (EDL) homogenates. In soleus from sedentary rats, superoxide dismutase and glutathione reductase activities were increased by 25% (P < 0.05) and by 40% (P < 0.01) after stanozolol administration, whereas catalase and glutathione peroxidase activities were not modified. This response was similar to that induced by training alone. In EDL from sedentary rats, stanozolol increased only superoxide dismutase activity (20%, P < 0.05). In no case, the effects of steroid administration and training were additive. HSP72 levels were up-regulated in soleus (1.5-fold, P < 0.01) and EDL (threefold, P < 0.001) following training but remained unchanged after stanozolol treatment. Endurance capacity, assessed in a treadmill endurance test, was similar for treated and control rats. We conclude that stanozolol treatment increases antioxidant capacity in selected skeletal muscles from sedentary rats. However, the steroid was not effective in improving endurance capacity or enhancing the training effects on muscle antioxidant defence systems.
File Format	HTM / HTML
ISSN	11387548
Issue Number	1
Volume Number	66
e-ISSN	18778755
Journal	Journal of Physiology and Biochemistry
Language	English
Publisher	Springer
Publisher Date	2010-03-01
Publisher Place	Spain
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Physiology Discipline Biochemistry Anabolic Agents Pharmacology Antioxidants Metabolism Muscle, Skeletal Drug Effects Stanozolol Animals Hsp72 Heat-shock Proteins Genetics Male Rats Rats, Wistar Journal Article
Content Type	Text
Resource Type	Article
Subject	Physiology Medicine Biochemistry

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in