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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Kang, Min-Jae Kim, Keun Ki Son, Byoung Yil Nam, Soo-Wan Shin, Pyung-Gyun Kim, Gun-Do |
| Description | Author Affiliation: Kang MJ ( Department of Microbiology, College of Natural Sciences, Pukyong National University, Busan 48513, Republic of Korea.); Kim KK ( Department of Life Science and Environmental Biochemistry, College of Natural Resource and Life Sciences, Pusan National University, Miryang 50463, Republic of Korea.); Son BY ( Blue-Bio Industry Regional Innovation Center, Dongeui University, Busan 47340, Republic of Korea.); Nam SW ( Department of Biotechnology and Bioengineering, Dongeui University, Busan 47340, Republic of Korea.); Shin PG ( Mushroom Research Division, National Institute of Horticultural and Herbal Science, Rural Development Administration, Eumseong 27709, Republic of Korea.); Kim GD ( Department of Microbiology, College of Natural Sciences, Pukyong National University, Busan 48513, Republic of Korea.) |
| Abstract | Adipogenesis is one of the cellular processes and a highly controlled program. Nowadays, inhibition of adipogenesis has received attention as an effective way to regulate obesity. In the current study, we investigated the inhibition effect of a chloroform extract of var. 'Beesan No. 2' (CEBT) on adipogenesis in 3T3-L1 murine preadipocytes. var. is one of many varieties of King oyster mushroom and has been reported to have various biological activities, including antitumor and anti-inflammation effects. Biological activities of 'Beesan No. 2', a new cultivar of var. , have not yet been reported. In this study, we found that CEBT suppressed adipogenesis in 3T3-L1 cells through inhibition of key adipogenic transcription factors, such as peroxisome proliferator-activated receptor γ and CCAAT/enhancer binding protein . Additionally, CEBT reduced the expression of the IRS/PI3K/Akt signaling pathway and its downstream factors, including mammalian target of rapamycin and p70S6 kinase, which stimulate adipogenesis. Furthermore, ß-catenin, a suppressor of adipogenesis, was increased in CEBT-treated cells. These results indicate that var. 'Beesan No. 2' effectively inhibited adipogenesis, so this mushroom has potential as an anti-obesity food and drug. |
| File Format | HTM / HTML |
| ISSN | 10177825 |
| e-ISSN | 17388872 |
| Journal | Journal of Microbiology and Biotechnology |
| Issue Number | 11 |
| Volume Number | 26 |
| Language | English |
| Publisher | Korean Society for Microbiology and Biotechnology |
| Publisher Date | 2016-11-28 |
| Publisher Place | Korea (South) |
| Access Restriction | Open |
| Subject Keyword | Discipline Microbiology Discipline Biotechnology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Applied Microbiology and Biotechnology Biotechnology |
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