NDLI: General assessment of copy number variation in normal and tumor tissues of the domestic dog (Canis lupus familiaris).

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General assessment of copy number variation in normal and tumor tissues of the domestic dog (Canis lupus familiaris).

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Gurgul, Artur Zukowski, Kacper Slaska, Brygida Semik, Ewelina Pawlina, Klaudia Zabek, Tomasz Jasielczuk, Igor Bugno-Poniewierska, Monika
Description	Author Affiliation: Gurgul A ( Laboratory of Genomics, National Research Institute of Animal Production, Krakowska 1, 32-083, Balice n. Krakow, Poland, artur.gurgul@izoo.krakow.pl.)
Abstract	In recent years, characterization of a copy number variation (CNV) of the genomic DNA has provided evidence for the relationship of this type of genetic variation with the occurrence of a broad spectrum of diseases, including cancer lesions. Copy number variants (CNVs) also occur in the genomes of healthy individuals as a result of abnormal recombination processes in germ cells and have a hereditary character contributing to the natural genetic diversity. Recent image analysis methods and advanced computational techniques allow for identification of CNVs using SNPs genotyping microarrays based on the analysis of signal intensity observed for markers located in the specific genomic regions. In this study we used CanineHD BeadChip assay (Illumina) to identify both natural and cancer-induced CNVs in the genomes of different dog breeds and in different cancer types occurring in this species. The obtained results showed that structural aberrations are a common phenomenon arising during a tumor progression and are more complex and widespread in tumors of mesenchymal tissue origin than in epithelial tissue originating tumors. The tumor derived CNVs, in comparison to healthy samples, were characterized by larger sizes of regions, higher number of amplifications, and in some cases encompassed genes with potential effect on tumor progression.
File Format	HTM / HTML
ISSN	12341983
Issue Number	3
Volume Number	55
e-ISSN	21903883
Journal	Journal of Applied Genetics
Language	English
Publisher	Springer
Publisher Date	2014-08-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Genetics Tumor Markers, Biological Genetics Dna Copy Number Variations Dog Diseases Neoplasms Veterinary Animals Chromosome Mapping Dogs Female Genome Genomics Male Polymorphism, Single Nucleotide Comparative Study Journal Article
Content Type	Text
Resource Type	Article
Subject	Genetics Medicine

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