NDLI: Effect of RET c.2307T>G Polymorphism on the Outcomes of Posterior Sagittal Neurectomy for Hirschsprung Disease Procedure in Indonesian Population.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Haryana, Sophia Mubarika Sadewa, Ahmad Hamim
Spatial Coverage	Indonesia
Description	Author Affiliation: Rochadi ( 1 Pediatric Surgery Division, Department of Surgery.)
Abstract	We investigated the effect of RET c.2307T>G polymorphism on the outcomes of posterior sagittal neurectomy for Hirschsprung disease (PSNHD) procedure in Indonesia. Hirschsprung disease (HSCR) is a neurocristopathy characterized by absence of enteric ganglia along variable lengths of the intestine in neonates. The RET c.2307T>G polymorphism has been shown to be associated with HSCR. Many surgical techniques with some advantage and disadvantage were established for HSCR. We have conducted PSNHD in short-segment HSCR patients.Thirty-one nonsyndromic HSCR patients underwent PSNHD. The polymorphism was determined using PCR-RFLP in genomic DNA. The rate of enterocolitis and constipation outcomes following PSNHD were 6 (19%) and 4 (13%) patients, respectively. The RET c.2307T>G polymorphism did not influence either enterocolitis or constipation outcome following PSNHD at P value of 0.07 (OR = 0.28; 95% CI = 0.08-1.05) and 0.67 (OR = 0.58; 95% CI = 0.12-2.76), respectively. Our study suggested that RET c.2307T>G polymorphism may not affect outcomes of PSNHD procedure in Indonesia. Furthermore, a multicenter study with a larger sample size is necessary to clarify this result.
File Format	HTM / HTML
ISSN	00208868
e-ISSN	25202456
DOI	10.9738/INTSURG-D-14-00082.1
Journal	International Surgery
Issue Number	6
Volume Number	99
Language	English
Publisher	International College of Surgeons
Publisher Date	2014-11-01
Publisher Place	Italy
Access Restriction	Open
Subject Keyword	Discipline General Surgery Hirschsprung Disease Genetics Surgery Polymorphism, Genetic Proto-oncogene Proteins C-ret Alleles Genetic Markers Genetic Predisposition To Disease Genotype Indonesia Infant Polymerase Chain Reaction Polymorphism, Restriction Fragment Length Questionnaires
Content Type	Text
Resource Type	Article
Subject	Surgery

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Effect of RET c.2307T>G Polymorphism on the Outcomes of Posterior Sagittal Neurectomy for Hirschsprung Disease Procedure in Indonesian Population

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Effect of RET c.2307T>G Polymorphism on the Outcomes of Posterior Sagittal Neurectomy for Hirschsprung Disease Procedure in Indonesian Population.

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Effect of RET c.2307T>G Polymorphism on the Outcomes of Posterior Sagittal Neurectomy for Hirschsprung Disease Procedure in Indonesian Population

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