NDLI: Isoflavone-rich soy isolate reduces lipid peroxidation in mouse liver.

Please wait, while we are loading the content...

Isoflavone-rich soy isolate reduces lipid peroxidation in mouse liver.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Ibrahim, Wissam H. Habib, Hosam M. Chow, Ching K. Bruckner, Geza G.
Description	Country affiliation: United Arab Emirates Author Affiliation: Ibrahim WH ( Department of Nutrition and Health, United Arab Emirates University, P.O.Box 17555, Al-Ain, United Arab Emirates. wibrahim@uaeu.ac.ae)
Abstract	The purpose of this study was to determine if an isoflavone-rich soy isolate affords protection against peroxidative damage in vivo. Weanling C57BL6 male mice were fed a basal diet (AIN-93G) supplemented with either nothing or 1.08 gram isoflavone-rich soy isolate/kg diet for 60 days. The soy isolate contained 400 mg/g isoflavone aglycones (226 mg/g genistein and 174 mg/g daidzein). Immediately following sacrifice liver was processed for measuring the levels of lipid peroxidation products, malondialdehyde (MDA) and conjugated dienes, and the levels of alpha-tocopherol, glutathione (GSH), and ascorbic acid, as well as the activities of catalase, selenium-dependent glutathione peroxidase (Se-GPx), selenium-nondependent glutathione peroxidase (non-Se-GPx), and superoxide dismutase (SOD). Compared with the control group, mice fed the diet supplemented with soy isolate had significantly (p<0.05) lower hepatic levels of MDA and conjugated dienes. The activities of catalase and SOD were significantly increased (p<0.05) in the liver of soy isolate-supplemented mice. The levels of vitamin E, GSH, and ascorbic acid and the activities of Se-GPx and non-Se-GPx were not significantly altered by the soy isolate. The results obtained provide experimental evidence that isoflavone supplementation confers protection against peroxidative damage to membrane lipids in vivo, possibly through enhancing the activities of the antioxidant enzymes catalase and SOD.
File Format	HTM / HTML
ISSN	03009831
Issue Number	4-5
Volume Number	78
e-ISSN	16642821
Journal	International Journal for Vitamin and Nutrition Research
Language	English
Publisher	Hans Huber
Publisher Date	2008-07-01
Publisher Place	Switzerland
Access Restriction	Subscribed
Subject Keyword	Discipline Nutritional Sciences Antioxidants Metabolism Pharmacology Genistein Isoflavones Lipid Peroxidation Drug Effects Liver Plant Extracts Soybeans Alkadienes Animals Ascorbic Acid Catalase Diet Administration & Dosage Glutathione Glutathione Peroxidase Malondialdehyde Mice Seeds Soybean Proteins Superoxide Dismutase Alpha-tocopherol Journal Article
Content Type	Text
Resource Type	Article
Subject	Nutrition and Dietetics Endocrinology, Diabetes and Metabolism

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in