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High Sensitive CRP Level Is Associated With Intermediate and High Syntax Score in Patients With Acute Coronary Syndrome.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Karadeniz, Muhammed Duran, Mustafa Akyel, Ahmet Yarlioglues, Mikail Öcek, Adil Hakan Çelik, Ibrahim Etem Kiliç, Alparslan Yalcin, Ahmet Arif Ergün, Gökhan Murat, Sani Namik
Spatial Coverage	Turkey
Description	Author Affiliation: Karadeniz M ( Department of Cardiology, Ankara Education and Research Hospital.)
Abstract	High sensitive C-reactive protein (hs-CRP) levels are associated with short- and long-term mortality in patients with acute coronary syndrome (ACS). We investigated whether baseline hs-CRP levels are associated with burden of coronary atherosclerosis assessed by SYNTAX score (SXScore).We enrolled 321 patients with ACS who underwent coronary angiography. The patients were divided into tertiles according to the SXScore: low SXScore (≤ 22), and intermediate-high SXScore (≥ 23).Subjects in the intermediate-high SXScore tertile had higher serum hs-CRP levels compare to low SXScore tertile patients (7.7 ± 3.4 mg/L versus 4.9 ± 2.5 mg/L, P < 0.001). The mean age of patients and prevalance of diabetes in the intermediate-high SXScore tertile were significantly higher than in the low SXScore tertile (63 ± 13 versus 58 ± 12 years P = 0.001 for age, P = 0.007 for diabetes). Multivariate logistic regression analysis showed that the strongest predictors of high SXScore were increased serum hs-CRP levels (OR: 1.14) together with multivessel disease (OR: 0.23), left ventricular ejection fraction (LVEF) (OR: 0.90), and troponin levels (OR: 1.12).Serum hs-CRP levels on admission in patients with ACS could predict the severity and complexity of coronary atherosclerosis together with multivessel disease, LVEF, and troponin levels. Thus, increased serum levels of hs-CRP were one of the strong predictors of high SXScore in ACS patients.
File Format	HTM / HTML
ISSN	13492365
e-ISSN	13493299
Journal	International Heart Journal
Issue Number	4
Volume Number	56
Language	English
Publisher	International Heart Journal Association
Publisher Date	2015-01-01
Publisher Place	Japan
Access Restriction	Open
Subject Keyword	Discipline Cardiology Acute Coronary Syndrome C-reactive Protein Metabolism Coronary Artery Disease Blood Diagnosis Etiology Coronary Angiography Complications Physiopathology Predictive Value Of Tests Regression Analysis Research Design Risk Assessment Risk Factors Severity Of Illness Index Troponin Turkey
Content Type	Text
Resource Type	Article
Subject	Cardiology and Cardiovascular Medicine

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