NDLI: Cost effectiveness of child pneumococcal conjugate vaccination in GAVI-eligible countries.

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Cost effectiveness of child pneumococcal conjugate vaccination in GAVI-eligible countries.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Tasslimi, Azadeh Nakamura, Mari M. Levine, Orin Knoll, Maria D. Russell, Louise B. Sinha, Anushua
Description	Country affiliation: United States Author Affiliation: Tasslimi A ( Department of Preventive Medicine and Community Health, University of Medicine & Dentistry of New Jersey-New Jersey Medical School, 185 South Orange Avenue, MSB F506, Newark, NJ 07101, USA.)
Abstract	Policy-makers increasingly rely on cost-effectiveness analysis, in addition to clinical effectiveness, when considering the introduction of new childhood vaccines. A previous analysis determined vaccination of infants with 7-valent pneumococcal conjugate vaccine (PCV) to be highly cost effective in preventing child mortality in countries eligible for financial support from the Global Alliance for Vaccines and Immunization (GAVI). We aimed to update this analysis by incorporating recent data on global disease burden, indirect effects and higher valency vaccines. Decision analytic models were built using an incidence-based approach in order to evaluate a three-dose vaccination schedule of infants in 72 GAVI-eligible countries over a 10-year programme. Seven-, 10- and 13-valent vaccine formulations were each compared with no vaccination. Depending on the formulation used, PCV could avert 294 000-603 000 deaths and 9.3-17.6 million disability-adjusted life-years (DALY) annually. The majority (91%) of the DALYs averted would be through the vaccine's direct effects in children under-5. Using WHO thresholds and a negotiated average dose cost, PCV would be highly cost effective in 69 of 72 GAVI-eligible countries. This finding was robust when assumptions regarding disease epidemiology and vaccine-related effects were varied in sensitivity analyses. The current analysis supports PCV introduction in GAVI-eligible countries owing to its potential to avert substantial numbers of deaths at relatively low incremental costs.
File Format	HTM / HTML
ISSN	18763413
Issue Number	4
Journal	International Health
Volume Number	3
e-ISSN	18763405
Language	English
Publisher	Oxford University Press
Publisher Date	2011-12-01
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Discipline Public Health Discipline Tropical Medicine
Content Type	Text
Resource Type	Article
Subject	Health (social science) Public Health, Environmental and Occupational Health

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