NDLI: Evaluation of telaprevir-containing triple therapy in the treatment of chronic hepatitis C in hemodialysed patients.

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Evaluation of telaprevir-containing triple therapy in the treatment of chronic hepatitis C in hemodialysed patients.

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Evaluation of telaprevir-containing triple therapy in the treatment of chronic hepatitis C in hemodialysed patients.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kaya, Safak Aksoz, Selcuk Baysal, Birol Ay, Nurettin Danis, Ramazan
Description	Country affiliation: Turkey Author Affiliation: Kaya S ( Department of Infectious Diseases, Gazi Yasargil Training and Research Hospital , Diyarbakir , Turkey.)
Abstract	Hepatitis C virus (HCV) infection is associated with increased morbidity and mortality in patients undergoing hemodialysis for end-stage renal disease (ESRD). Eradication of HCV before transplantation is therefore of utmost importance in HCV-infected patients with ESRD who are candidates for kidney transplantation. The appropriate treatment for HCV infection in patients with ESRD and suboptimal response rates is still unclear. Here, we present our data from five cases who were being monitored by two healthcare centers for ESRD and HCV infection, who were candidates for kidney transplantation and were treated with a triple regimen containing telaprevir. All patients were started on triple therapy from the beginning including pegylated interferon-alfa2a (135 µg once a week), ribavirin (200 mg three times a week), and telaprevir (750 mg three times a day). Rapid virologic response was observed in all of the patients but treatment was discontinued in one patient at week 6 because the patient developed nausea and vomiting and was unable to feed orally. For the remaining four patients, side effects included weakness, lack of appetite, metallic taste, and mild anemia. The triple therapy with telaprevir seemed to be successful in HCV-infected patients who were candidates for renal transplantation.
File Format	HTM / HTML
ISSN	23744235
Issue Number	9
Volume Number	47
e-ISSN	23744243
Journal	Infectious Diseases
Language	English
Publisher	Taylor & Francis
Publisher Date	2015-09-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Communicable Diseases Antiviral Agents Adverse Effects Therapeutic Use Hepatitis C, Chronic Drug Therapy Oligopeptides Adult Drug Therapy, Combination Female Humans Interferon-alpha Male Middle Aged Polyethylene Glycols Recombinant Proteins Renal Dialysis Ribavirin Case Reports Journal Article
Content Type	Text
Resource Type	Case study Article
Subject	Infectious Diseases Immunology and Microbiology Microbiology (medical)

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