NDLI: Genotypic determination of HIV tropism in a cohort of patients perinatally infected with HIV-1 and exposed to antiretroviral therapy.

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Genotypic determination of HIV tropism in a cohort of patients perinatally infected with HIV-1 and exposed to antiretroviral therapy.

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Genotypic determination of HIV tropism in a cohort of patients perinatally infected with HIV-1 and exposed to antiretroviral therapy.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Di Biagio, Antonio Parisini, Andrea Bruzzone, Bianca Prinapori, Roberta Lauriola, Marinella Paolucci, Stefania Signori, Alessio Barresi, Renata Icardi, Giancarlo Calderisi, Silvia Meini, Genny Dentone, Chiara Cenderello, Giovanni Guerra, Michele Maccabruni, Anna Rusconi, Stefano Viscoli, Claudio
Description	Country affiliation: Italy Author Affiliation: Di Biagio A ( Infectious Diseases, IRCCS San Martino Hospital, University of Genoa, IST, Genoa, Italy.); Parisini A ( Infectious Diseases, IRCCS San Martino Hospital, University of Genoa, IST, Genoa, Italy.); Bruzzone B ( Hygiene Unit, IRCCS San Martino Hospital, University of Genoa, IST, Genoa, Italy.); Prinapori R ( Infectious Diseases, IRCCS San Martino Hospital, University of Genoa, IST, Genoa, Italy.); Lauriola M ( Infectious Diseases, University of Pavia, IRCCS Policlinico San Matteo, Pavia, Italy.); Paolucci S ( Molecular Virology Unit, Virology and Microbiology, IRCCS Policlinico San Matteo, Pavia, Italy.); Signori A ( Biostatistic Unit, Department of Health Sciences, Genoa, Italy.); Barresi R ( Hygiene Unit, IRCCS San Martino Hospital, University of Genoa, IST, Genoa, Italy.); Icardi G ( Hygiene Unit, IRCCS San Martino Hospital, University of Genoa, IST, Genoa, Italy.); Calderisi S ( Hygiene Unit, IRCCS San Martino Hospital, University of Genoa, IST, Genoa, Italy.); Meini G ( Section of Microbiology, Department of Molecular Biology, University of Siena, Siena, Italy.); Dentone C ( Infectious Diseases, San Remo Hospital, San Remo, Italy.); Cenderello G ( Infectious Diseases, EO Galliera, Genoa, Italy.); Guerra M ( Infectious Diseases, La Spezia Hospital, La Spezia, Italy.); Maccabruni A ( Infectious Diseases, University of Pavia, IRCCS Policlinico San Matteo, Pavia, Italy.); Rusconi S ( Infectious Diseases, University of Milan, DISC Luigi Sacco, Milan, Italy.); Viscoli C ( Infectious Diseases, IRCCS San Martino Hospital, University of Genoa, IST, Genoa, Italy.)
Abstract	The aim of this study was to determine the coreceptor tropism by performing genotypic HIV-1 tropism testing in a cohort of patients perinatally infected with HIV-1 and exposed to antiretroviral therapy. Genotypic coreceptor tropism was determined in patients with HIV-1 RNA<100 copies/mL using PBMC samples by gp120 V3 sequencing followed by geno2pheno interpretation (set at a false positive rate [FPR] of 20%) and in patients with â¯100 copies/mL using plasma samples (set at a FPR of 20%), according to European guidelines. Out of 55 patients, 50 had an HIV-1 subtype B strain, and mean (SD) age was 18.2 (4.6) years. The median duration of antiretroviral therapy was 13 years (range, 3-23). Thirty-three (60%) patients harbored the R5 virus. At the time of the testing, the median CD4+ T lymphocyte cell count and percentage were 705 cells/mm3 (474-905) and 32.5% in group R5 and 626 cells/mm3 (450-755) and 31.7% in group X4/D-M, respectively. The nadir of CD4+ T-cell count in groups R5 and X4/D-M were 322 cells/mm3 (230-427) and 340 cells/mm3 (242-356), respectively. These differences were not statistically significant. Fifteen patients had HIV-1 RNA â¯50 copies/mL. The median HIV-1 RNA and HIV-1 DNA were comparable in both groups without a statistical difference. The study provides an overview of the prevalence of coreceptor tropism in a cohort of patients who were vertically infected with HIV-1. The high prevalence of X4/D-M-tropic strains may simply reflect the long-term exposure to HIV.
File Format	HTM / HTML
ISSN	15284336
Issue Number	1
Volume Number	15
e-ISSN	19455771
Journal	HIV Clinical Trials
Language	English
Publisher	Taylor & Francis
Publisher Date	2014-01-01
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Discipline Acquired Immunodeficiency Syndrome Discipline Therapeutics Acquired Immunodeficiency Syndrome Drug Therapy Anti-retroviral Agents Therapeutic Use Hiv-1 Classification Viral Tropism Virology Adolescent Adult Cd4 Lymphocyte Count Child Child, Preschool Cohort Studies Female Genotype Genetics Humans Male Viral Load Journal Article
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases Pharmacology (medical)

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