NDLI: Macrophage responses to CF pathogens: JNK MAP kinase signaling by Burkholderia cepacia complex lipopolysaccharide.

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Macrophage responses to CF pathogens: JNK MAP kinase signaling by Burkholderia cepacia complex lipopolysaccharide.

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Macrophage responses to CF pathogens: JNK MAP kinase signaling by Burkholderia cepacia complex lipopolysaccharide.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	McKeon, Suzanne McClean, Siobhán Callaghan, Máire
Description	Country affiliation: Ireland Author Affiliation: McKeon S ( Centre of Microbial Host Interactions, ITT-Dublin, Dublin, Ireland.)
Abstract	Chronic bacterial colonization of the airways with opportunistic pathogens is the primary cause of morbidity and mortality in cystic fibrosis (CF) patients. Burkholderia cepacia complex (Bcc) organisms pose a particular challenge in CF lung disease, due in part to their ability to trigger a fulminant pneumonia. This study compares the U937 macrophage response to two Bcc species, B. cenocepacia and Burkholderia multivorans, against Pseudomonas aeruginosa and Staphylococcus aureus. The two Bcc strains demonstrated higher levels of U937 macrophage internalization compared with both P. aeruginosa and S. aureus. Both the Bcc strains also stimulated significantly greater levels of tumor necrosis factor- and interleukin-1ß from macrophages when compared with P. aeruginosa. Further examination of the macrophage response to B. multivorans demonstrated that the lipopolysaccharide component of these bacteria was a potent inducer of proinflammatory cytokines and was shown to signal predominantly through the c-Jun N-terminal kinase mitogen-activated protein kinase pathway. These studies further characterize the host response to Bcc and in particular B. multivorans, now the predominant Bcc species in many CF populations.
File Format	HTM / HTML
ISSN	09288244
e-ISSN	1574695X
Journal	FEMS Immunology & Medical Microbiology
Issue Number	1
Volume Number	60
Language	English
Publisher	Elsevier
Publisher Date	2010-10-01
Publisher Place	Great Britain (UK)
Access Restriction	Open
Subject Keyword	Discipline Microbiology Discipline Immunology Burkholderia Cepacia Complex Immunology Cytokines Secretion Jnk Mitogen-activated Protein Kinases Metabolism Lipopolysaccharides Macrophages Signal Transduction Cell Line Cytoplasm Microbiology Pseudomonas Aeruginosa Staphylococcus Aureus Comparative Study Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases Immunology and Allergy Immunology Microbiology Microbiology (medical)

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