NDLI: Novel diagnostic and prognostic biomarkers in biliary tract cancer.

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Novel diagnostic and prognostic biomarkers in biliary tract cancer.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Skipworth, James R. A. Timms, John F. Pereira, Stephen P.
Description	Country affiliation: United kingdom Author Affiliation: Skipworth JR ( University College London, Division of Surgery and Interventional Science, 4th Floor, 74 Huntley Street, London, WC1E6AU, UK.)
Abstract	INTRODUCTION: The worldwide incidence of biliary tract carcinoma (BTC, tumours of the bile ducts and gall-bladder) continues to rise, with the only potentially curative treatment remaining surgical resection or transplantation, possible in only a minority of patients. Late presentation and a paucity of effective treatments mandate the development of techniques for early lesion detection. AREAS COVERED: This article reviews currently available biomarkers for the diagnosis and prognosis of BTC, as well as recently published studies describing novel serum, bile and urinary biomarkers. EXPERT OPINION: The incorporation of novel analysis techniques, such as digital image analysis and fluorescence in situ hybridization, into existing management algorithms enhances the accuracy of brush cytology taken at the time of therapeutic endoscopy. However, a key goal is the discovery of reliable non-invasive biomarkers with high sensitivity and specificity. Recent advances in gene sequencing and expression, clonal evolution and tumour heterogeneity in other cancers should advance understanding of BTC tumour biology and facilitate biomarker discovery.
File Format	HTM / HTML
ISSN	17530059
Issue Number	5
Journal	Expert Opinion on Medical Diagnostics
Volume Number	7
e-ISSN	17530067
Language	English
Publisher	Taylor & Francis
Publisher Date	2013-09-01
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Discipline Diagnostic Imaging Discipline Clinical Laboratory Techniques Biliary Tract Neoplasms Diagnosis Tumor Markers, Biological Analysis Metabolism Humans Prognosis Journal Article Review
Content Type	Text
Resource Type	Article
Subject	Biochemistry (medical) Molecular Medicine Biomedical Engineering

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