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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Berruti, Alfredo Ferrero, Anna Sperone, Paola Daffara, Fulvia Reimondo, Giuseppe Papotti, Mauro Dogliotti, Luigi Angeli, Alberto Terzolo, Massimo |
| Description | Country affiliation: Italy Author Affiliation: Berruti A ( Department of Clinical and Biological Science, Oncologia Medica, University of Turin, Azienda Ospedaliera San Luigi, Regione Gonzole 10, 10043 Orbassano, Italy. alfredo.berruti@gmail.com) |
| Abstract | BACKGROUND: Adrenocortical carcinoma (ACC) is an extremely rare aggressive disease. Few data are available on the efficacy of systemic antineoplastic treatments (mitotane and cytotoxic therapy) in the treatment of advanced disease. OBJECTIVE/METHODS: this paper will review the existing treatment strategies and new perspectives in the management of ACC patients. RESULTS/CONCLUSION: An ongoing randomized international trial aims to define the best combination chemotherapy plus mitotane regimen. Based on the results of a case control study, mitotane is being explored as adjuvant therapy. Genetic and biological studies have identified molecular targets for specific targeted drugs such as IGF receptor inhibitors and antiangiogenetic drugs. Phase II trials are exploring the activity of these drugs either alone or in combination with chemotherapy. |
| File Format | HTM / HTML |
| ISSN | 14728214 |
| Issue Number | 3 |
| Volume Number | 13 |
| e-ISSN | 17447623 |
| Journal | Expert Opinion on Emerging Drugs |
| Language | English |
| Publisher | Taylor & Francis |
| Publisher Date | 2008-09-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Drug Therapy Adrenal Cortex Neoplasms Drug Therapy Adrenocortical Carcinoma Antineoplastic Agents, Hormonal Therapeutic Use Antineoplastic Combined Chemotherapy Protocols Mitotane Administration & Dosage Chemotherapy, Adjuvant Humans Journal Article Research Support, Non-u.s. Gov't Review |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology Pharmacology (medical) |
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