NDLI: Stress amplifies lung tissue mechanics, inflammation and oxidative stress induced by chronic inflammation.

Please wait, while we are loading the content...

Stress amplifies lung tissue mechanics, inflammation and oxidative stress induced by chronic inflammation.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Reis, Fabiana G. Marques, Ricardo H. Starling, Claudia M. Almeida-Reis, Rafael Vieira, Rodolfo P. Cabido, Claudia T. Silva, Luiz Fernando F. Lanças, Tatiana Dolhnikoff, Marisa Martins, Mílton A. Leick-Maldonado, Edna A. Prado, Carla M. Tibério, Iolanda F. L. C.
Description	Country affiliation: Brazil Author Affiliation: Reis FG ( Medicine Department LIM, School of Medicine, University of São Paulo, São Paulo, Brazil.)
Abstract	BACKGROUND: Mechanisms linking behavioral stress and inflammation are poorly understood, mainly in distal lung tissue. OBJECTIVE: We have investigated whether the forced swim stress (FS) could modulate lung tissue mechanics, iNOS, cytokines, oxidative stress activation, eosinophilic recruitment, and remodeling in guinea pigs (GP) with chronic pulmonary inflammation. METHODS: The GP were exposed to ovalbumin or saline aerosols (2×/wk/4wks, OVA, and SAL). Twenty-four hours after the 4th inhalation, the GP were submitted to the FS protocol (5×/wk/2wks, SAL-S, and OVA-S). Seventy-two hours after the 7th inhalation, lung strips were cut and tissue resistance (Rt) and elastance (Et) were obtained (at baseline and after OVA and Ach challenge). Strips were submitted to histopathological evaluation. RESULTS: The adrenals' weight, the serum cortisol, and the catecholamines were measured. There was an increase in IL-2, IL-5, IL-13, IFN-Î³, iNOS, 8-iso-PGF2 , and in %Rt and %Et after Ach challenge in the SAL-S group compared to the SAL one. The OVA-S group has had an increase in %Rt and %Et after the OVA challenge, in %Et after the Ach and in IL-4, 8-iso-PGF2 , and actin compared to the OVA. Adrenal weight and cortisol serum were increased in stressed animals compared to nonstressed ones, and the catecholamines were unaltered. CONCLUSION & CLINICAL RELEVANCE: Repeated stress has increased distal lung constriction, which was associated with an increase of actin, IL-4, and 8-iso-PGF2 levels. Stress has also induced an activation of iNOS, cytokines, and oxidative stress pathways.
File Format	HTM / HTML
ISSN	01902148
Issue Number	7
Volume Number	38
e-ISSN	15210499
Journal	Experimental Lung Research
Language	English
Publisher	Taylor & Francis
Publisher Date	2012-09-01
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Discipline Pulmonary Medicine Lung Physiopathology Oxidative Stress Physiology Pneumonia Stress, Psychological Actins Analysis Adrenal Glands Anatomy & Histology Airway Resistance Animals Catecholamines Blood Chronic Disease Cytokines Dinoprost Eosinophils Guinea Pigs Hydrocortisone Pathology Male Nitric Oxide Synthase Type Ii Organ Size Chemically Induced Psychology Swimming Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Pulmonary and Respiratory Medicine Molecular Biology Clinical Biochemistry

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in