NDLI: The acute effect of cigarette smoking on the respiratory function and FENO production among young smokers.

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The acute effect of cigarette smoking on the respiratory function and FENO production among young smokers.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kougias, Marios Vardavas, Constantine I. Anagnostopoulos, Nektarios Matsunaga, Yuko Tzwrtzi, Anna Lymberi, Maria Connolly, Gregory N. Behrakis, Panagiotis K.
Description	Country affiliation: Greece Author Affiliation: Kougias M ( 1Department of Physiology, School of Medicine, University of Athens , Greece.)
Abstract	INTRODUCTION: Smoking is known to have a long-term impact on lung function; however, the acute physiological response of smoking a single cigarette and the influential role of pack years and cigarettes per day on pulmonary indices remains an area of interest, especially among young smokers. METHODS: 50 naive smokers (ages: 18-26, 24 males: mean pack years 3.8) participated in this experimental study. Respiratory resistance (R), reactance (X), and impedance (Z) were assessed through impulse oscillometry. The participants' fraction of exhaled nitric oxide (FENO) was measured. All tests were performed immediately before and after smoking one single cigarette. RESULTS: Smoking a single cigarette was found to immediately increase airway impedance (Z 5 Hz) by 0.024 kPa/(L/s) (P = .002), airway resistance at R 5 Hz, R 10 Hz, and R 20 Hz by 0.024 kPa/(L/s)(P < .001), 0.016 kPa/(L/s)(P = .019), and 0.023 kPa/(L/s) (P = .007), respectively, after adjusting for BMI, age, gender, and pack years. FENO concentrations also decreased from 11.70 ppb to 9.85 ppb, P < .001. Sensitivity analyses indicated that the participants' number of pack years and cigarettes per day influenced pulmonary reactance at 10 Hz and 20 Hz, however only at baseline with these differences found to disappear immediately after smoking. CONCLUSIONS: The present study indicates that the consumption of a single cigarette may alter lung mechanics and FENO production among young smokers. Further research is needed to assess the mechanisms and washout period after which these parameters return to normal.
File Format	HTM / HTML
ISSN	01902148
Issue Number	8
Volume Number	39
e-ISSN	15210499
Journal	Experimental Lung Research
Language	English
Publisher	Taylor & Francis
Publisher Date	2013-10-01
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Discipline Pulmonary Medicine Respiratory Mechanics Smoking Adverse Effects Physiopathology Adolescent Adult Airway Resistance Exhalation Female Humans Lung Volume Measurements Male Nitric Oxide Metabolism Respiratory Function Tests Young Adult Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Pulmonary and Respiratory Medicine Molecular Biology Clinical Biochemistry

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