NDLI: Glitazones in type 2 diabetes: an update.

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Glitazones in type 2 diabetes: an update.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Abstract	The glitazones and their combination products are licensed for type 2 diabetes mellitus and now account for over 50% of NHS expenditure on oral hypoglycaemic drugs. In 2001, for pioglitazone and rosiglitazone (the two glitazones licensed in the UK), we concluded that evidence (from short-term studies) supported their use in combination with metformin or a sulphonylurea in patients unsuited to one or other of these drugs, but not more practical glitazone use, such as monotherapy or as part of triple therapy. We also said that their long-term effects were not yet clear. Since then, both drugs have also been licensed for monotherapy, as part of triple therapy that includes metformin and a sulphonylurea and, for pioglitazone, use with insulin. Here we reassess glitazones in light of published efficacy data and safety concerns raised in recent years.
File Format	HTM / HTML
ISSN	00126543
Issue Number	4
Volume Number	46
e-ISSN	17555248
Journal	Drug and Therapeutics Bulletin
Language	English
Publisher	BMJ Publishing Group
Publisher Date	2008-04-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Pharmacology Diabetes Mellitus, Type 2 Drug Therapy Diabetic Angiopathies Hypoglycemic Agents Therapeutic Use Thiazolidinediones Drug Therapy, Combination Humans Adverse Effects Randomized Controlled Trials As Topic Treatment Outcome Journal Article Review
Content Type	Text
Resource Type	Article
Subject	Pharmacology (medical)

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