NDLI: Targinact--opioid pain relief without constipation?

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Targinact--opioid pain relief without constipation?

Content Provider	World Health Organization (WHO)-Global Index Medicus
Abstract	Targinact (Napp Pharmaceuticals Ltd) is a modified-release combination product containing the strong opioid oxycodone plus the opioid antagonist naloxone. It is licensed for 'severe pain, which can be adequately managed only with opioid analgesics'.1 The summary of product characteristics (SPC) states that 'naloxone is added to counteract opioid-induced constipation by blocking the action of oxycodone at opioid receptors locally in the gut'. Advertising for the product claims 'better pain relief', 'superior GI [gastrointestinal] tolerability' and 'improved quality of life' 'compared to previous treatment in a clinical practice study (n=7836)'. Here we consider whether Targinact offers advantages over using strong opioids plus laxatives where required.
File Format	HTM / HTML
ISSN	00126543
Issue Number	12
Volume Number	48
e-ISSN	17555248
Journal	Drug and Therapeutics Bulletin
Language	English
Publisher	BMJ Publishing Group
Publisher Date	2010-12-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Pharmacology Analgesics, Opioid Administration & Dosage Pain Prevention & Control Adverse Effects Constipation Chemically Induced Delayed-action Preparations Drug Combinations Follow-up Studies Humans Naloxone Oxycodone Randomized Controlled Trials As Topic Journal Article
Content Type	Text
Resource Type	Article
Subject	Pharmacology (medical)

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