NDLI: Coenzyme Q10 and statin-related myopathy.

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Coenzyme Q10 and statin-related myopathy.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Abstract	Statins inhibit the enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, which is involved in the production of mevalonic acid in the cholesterol biosynthesis pathway. This pathway also results in the production of other bioactive molecules including coenzyme Q10 (also known as ubiquinone or ubidecarenone). Coenzyme Q10 is a naturally-occurring coenzyme with antioxidant effects that is involved in electron transport in mitochondria and is thought to play a role in energy transfer in skeletal muscle. Muscle-related problems are a frequently reported adverse effect of statins, and it has been hypothesised that a reduced endogenous coenzyme Q10 concentration is a cause of statin-induced myopathy. Coenzyme Q10 supplementation has therefore been proposed to reduce the adverse muscular effects sometimes seen with statins. Here, we consider whether coenzyme Q10 has a place in the management of statin-induced myopathy.
File Format	HTM / HTML
ISSN	00126543
Issue Number	5
Volume Number	53
e-ISSN	17555248
Journal	Drug and Therapeutics Bulletin
Language	English
Publisher	BMJ Publishing Group
Publisher Date	2015-05-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Pharmacology Hydroxymethylglutaryl-coa Reductase Inhibitors Adverse Effects Muscular Diseases Drug Therapy Ubiquinone Analogs & Derivatives Energy Transfer Physiology Humans Hydroxymethylglutaryl Coa Reductases Drug Effects Metabolism Pharmacology Mevalonic Acid Chemically Induced Administration & Dosage Journal Article
Content Type	Text
Resource Type	Article
Subject	Pharmacology (medical)

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