NDLI: Plasma interleukin-1beta, -6, -8 and tumor necrosis factor-alpha as highly informative markers of pelvic inflammatory disease.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Lee, Shun-An Tsai, Hsiu-Ting Ou, Hsiu-Chung Han, Chih-Ping Tee, Yi-Torng Chen, Yi-Chen Wu, Ming-Tsang Chou, Ming-Chin Wang, Po-Hui Yang, Shun-Fa
Description	Country affiliation: Taiwan Author Affiliation: Lee SA ( Institute of Medicine, Chung Shan Medical University, Lee's General Hospital, Ta-Chia, Taichung, Taiwan.)
Abstract	BACKGROUND: The role of proinflammatory cytokines in pelvic inflammatory disease (PID) is unclear. We therefore determined whether plasma proinflammatory cytokines, interleukin-1beta (IL-1beta), IL-6, IL-8 and tumor necrosis factor-alpha (TNF-alpha) were useful plasma markers in PID patients. METHODS: Multiplex bead array analysis was used to measure the plasma levels of proinflammatory cytokines in 50 healthy controls as well as in 41 PID patients before and after routine protocol treatments. RESULTS: IL-1beta, IL-6, IL-8 and TNF-alpha were significantly elevated in PID patients before antibiotic treatment than after treatment. However, IL-8 was not significantly different between healthy controls and PID patients. The relative increase in ratio of IL-6 was significantly correlated with white blood cell count (r=0.448, p=0.003), neutrophil count (r=0.472, p=0.002) and C-reactive protein level (r=0.412, p=0.008). CONCLUSIONS: IL-1beta, IL-6, IL-8 and TNF-alpha may play an important role in the pathogenesis of PID. These biomarkers, particularly IL-6, could be useful adjuncts for the clinical diagnosis of PID.
File Format	HTM / HTML
ISSN	14346621
Issue Number	7
Volume Number	46
e-ISSN	14374331
Journal	Clinical Chemical Laboratory Medicine
Language	English
Publisher	De Gruyter
Publisher Date	2008-01-01
Publisher Place	Germany
Access Restriction	Subscribed
Subject Keyword	Discipline Clinical Discipline Chemistry Interleukin-1beta Blood Interleukin-6 Interleukin-8 Pelvic Inflammatory Disease Immunology Tumor Necrosis Factor-alpha Biological Markers Female Humans Diagnosis Journal Article
Content Type	Text
Resource Type	Article
Subject	Biochemistry (medical) Clinical Biochemistry

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