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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Vasanthakumar, Aparna Godley, Lucy A. |
| Description | Country affiliation: United States Author Affiliation: Vasanthakumar A ( Section of Hematology/Oncology, Department of Medicine, The University of Chicago, Chicago, IL, USA.); Godley LA ( Section of Hematology/Oncology, Department of Medicine, The University of Chicago, Chicago, IL, USA. Electronic address: lgodley@medicine.bsd.uchicago.edu.) |
| Abstract | Emerging data have demonstrated that 5-methylcytosine (5-mC) and its oxidized products 5-hydroxymethylcytosine (5-hmC), 5-formylcytosine (5-fC), and 5-carboxylcytosine (5-CaC) play unique roles in several biological processes, including the control of gene expression and in the pathogenesis of cancer. In this review, we focus on 5-hmC and the disruption of its distribution in several cancers, including hematological malignancies and solid tumors. We present an outline of how 5-hmC is closely associated with metabolic pathways and may be the missing link connecting epigenetics with metabolism in the context of cancer cells. Finally, we discuss the diagnostic and prognostic importance of 5-mC and 5-hmC patterning, and how we may be able to establish new paradigms in cancer therapy based on these alterations. |
| File Format | HTM / HTML |
| ISSN | 22107762 |
| Issue Number | 5 |
| Volume Number | 208 |
| Journal | Cancer Genetics |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-05-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Genetics Discipline Neoplasms Discipline Medical 5-methylcytosine Metabolism Cytosine Analogs & Derivatives Dna Methylation Neoplasms Diagnosis Therapy Dna (cytosine-5-)-methyltransferase Dna-binding Proteins Genetics Humans Isocitrate Dehydrogenase Proto-oncogene Proteins Journal Article Research Support, N.i.h., Extramural Review |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Molecular Biology Cancer Research |
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