NDLI: Bisphenol A: developmental toxicity from early prenatal exposure.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Golub, Mari S. Wu, Katherine Lily Kaufman, Farla L. Li, Ling-Hong Moran-Messen, Francisco Zeise, Lauren Alexeeff, George V. Donald, James M.
Description	Country affiliation: United States Author Affiliation: Golub MS ( Office of Environmental Health Hazard Assessment, Reproductive and Cancer Hazard Assessment Branch, Sacramento, California, USA. mgolub@oehha.ca.gov)
Abstract	Bisphenol A (BPA) exposure has been documented in pregnant women, but consequences for development are not yet widely studied in human populations. This review presents research on the consequences for offspring of BPA exposure during pregnancy. Extensive work in laboratory rodents has evaluated survival and growth of the conceptus, interference with embryonic programs of development, morphological sex differentiation, sex differentiation of the brain and behavior, immune responsiveness, and mechanism of action. Sensitive measures include RAR, aryl hydrocarbon receptor, and Hox A10 gene expression, anogenital distance, sex differentiation of affective and exploratory behavior, and immune hyperresponsiveness. Many BPA effects are reported at low doses (10-50 µg/kg d range) by the oral route of administration. At high doses (>500,000 µg/kg d) fetal viability is compromised. Much of the work has centered around the implications of the estrogenic actions of this agent. Some work related to thyroid mechanism of action has also been explored. BPA research has actively integrated current knowledge of developmental biology, concepts of endocrine disruption, and toxicological research to provide a basis for human health risk assessment.
File Format	HTM / HTML
ISSN	15429733
Issue Number	6
Volume Number	89
e-ISSN	15429741
Journal	Birth Defects Research Part B: Developmental and Reproductive Toxicology
Language	English
Publisher	Wiley
Publisher Date	2010-12-01
Publisher Place	United States
Access Restriction	Subscribed
Subject Keyword	Discipline Teratology Discipline Toxicology Abnormalities, Drug-induced Etiology Embryo, Mammalian Drug Effects Embryonic Development Estrogens, Non-steroidal Toxicity Fetal Development Maternal Exposure Adverse Effects Phenols Epidemiology Animals Benzhydryl Compounds Female Humans Male Pregnancy Sex Differentiation Journal Article Review
Content Type	Text
Resource Type	Article
Subject	Developmental Biology Health, Toxicology and Mutagenesis Toxicology Embryology

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