NDLI: Neurotoxicity assessment of artemether in juvenile rats.

Please wait, while we are loading the content...

Year: 2016 Volume: 107

Year: 2015 Volume: 104

Year: 2014 Volume: 101

Year: 2013 Volume: 98

Year: 2013 Volume: 98 Issue: 6

Year: 2013 Volume: 98 Issue: 5

Year: 2013 Volume: 98 Issue: 4

Year: 2013 Volume: 98 Issue: 3

Year: 2013 Volume: 98 Issue: 2

Cancer risks in parents who had a child with a congenital malformation.

Decreased expression of GATA4 in the diaphragm of nitrofen-induced congenital diaphragmatic hernia.

Effect of PPARß/Î´ agonist on the placentation and embryo-fetal development in rats.

Neurotoxicity assessment of artemether in juvenile rats.

A review of developmental and reproductive toxicity of CS2 and H2 S generated by the pesticide sodium tetrathiocarbonate.

The teratogenic effect of dofetilide during rat limb development and association with drug-induced bradycardia and hypoxia in the embryo.

The effects of shipping on early pregnancy in laboratory rats.

The effects of interleukin-6 signal blockade on immune system, reproductive and skeletal development in juvenile mice.

Year: 2013 Volume: 98 Issue: 1

Year: 2012 Volume: 95

Year: 2011 Volume: 92

Year: 2010 Volume: 89

Year: 2009 Volume: 86

Year: 2008 Volume: 83

Year: 2007 Volume: 80

Neurotoxicity assessment of artemether in juvenile rats.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Beckman, David A. Youreneff, Maureen Butt, Mark T.
Description	Country affiliation: United States Author Affiliation: Beckman DA ( Preclinical Safety, Novartis Institute for Biomedical Research, East Hanover, New Jersey 07936, USA. david.beckman@novartis.com)
Abstract	BACKGROUND: Oral administration of artemether in combination with lumefantrine is approved for the treatment of malaria in adults and children. In adult animals, artemether can produce neurotoxicity with intramuscular, but not oral, administration. Herein, the potential of orally administered artemether to produce neurotoxicity in juvenile rats was investigated. METHODS: In the first study, the toxicity of artemether was evaluated in juvenile rats dosed with 0, 10, 30, and 100mg/kg/day on postpartum days (ppds) 7 to 21. In-life, clinical pathology, anatomic pathology, behavioral, and toxicokinetics evaluations were performed. The second study focused on neurotoxicity during different dosing intervals, with doses of 0, 30, and 80 mg/kg/day on ppds 7 to 13, and doses of 0, 30, and 120 mg/kg/day on ppds 14 to 21, 22 to 28, and 29 to 36. For each dosing interval, in-life, extensive histology, toxicokinetics, and behavioral evaluations were performed. In the third study, toxicokinetics evaluations in the adult were conducted at 20 and 200 mg/kg/day. RESULTS: The first study demonstrated increased mortality, renal necrosis, and brain hemorrhage at ≥30 mg/kg/day with no persistent effects in surviving animals. In the second study, increased mortality, body weight effects, and a trend toward increased exposure were observed in the ppd 14 and younger animals. Neither specific neurotoxicity nor persistent effects were seen. The toxicokinetic study in adults revealed lower exposures as compared to those in the younger juvenile rats. CONCLUSIONS: As in the adult rat, oral administration of artemether in the juvenile rat is not associated with the neurotoxicity produced by intramuscular administration.
File Format	HTM / HTML
ISSN	15429733
Issue Number	2
Volume Number	98
e-ISSN	15429741
Journal	Birth Defects Research Part B: Developmental and Reproductive Toxicology
Language	English
Publisher	Wiley
Publisher Date	2013-04-01
Publisher Place	United States
Access Restriction	Subscribed
Subject Keyword	Discipline Teratology Discipline Toxicology Antimalarials Administration & Dosage Toxicity Artemisinins Neurotoxicity Syndromes Pathology Administration, Oral Animals Pharmacokinetics Body Weight Drug Effects Dose-response Relationship, Drug Ethanolamines Female Fluorenes Kinetics Male No-observed-adverse-effect Level Rats Rats, Wistar Toxicity Tests Journal Article
Content Type	Text
Resource Type	Article
Subject	Developmental Biology Health, Toxicology and Mutagenesis Toxicology Embryology

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in