NDLI: Dual-drug delivery of curcumin and platinum drugs in polymeric micelles enhances the synergistic effects: a double act for the treatment of multidrug-resistant cancer.

Please wait, while we are loading the content...

Year: 2017 Volume: 5

Year: 2016 Volume: 4

Year: 2015 Volume: 3

Year: 2015 Volume: 3 Issue: 12

Year: 2015 Volume: 3 Issue: 11

Year: 2015 Volume: 3 Issue: 10

Year: 2015 Volume: 3 Issue: 9

Year: 2015 Volume: 3 Issue: 8

Year: 2015 Volume: 3 Issue: 7

Year: 2015 Volume: 3 Issue: 6

Year: 2015 Volume: 3 Issue: 5

Year: 2015 Volume: 3 Issue: 4

Year: 2015 Volume: 3 Issue: 3

Year: 2015 Volume: 3 Issue: 2

Year: 2015 Volume: 3 Issue: 1

Cell-derived matrices for tissue engineering and regenerative medicine applications.

In Vitro Study of Directly Bioprinted Perfusable Vasculature Conduits.

MMP9-sensitive polymers mediate environmentally-responsive bivalirudin release and thrombin inhibition.

Polymeric 3D nano-architectures for transport and delivery of therapeutically relevant biomacromolecules.

Elastomeric nanocomposite scaffolds made from poly(glycerol sebacate) chemically crosslinked with carbon nanotubes.

Cancer-targeted near infrared imaging using rare earth ion-doped ceramic nanoparticles.

Sustained delivery of bioactive neurotrophin-3 to the injured spinal cord.

Heparin-induced conformational changes of fibronectin within the extracellular matrix promote hMSC osteogenic differentiation.

Biomimetic honeycomb-patterned surface as the tunable cell adhesion scaffold.

Patterning of supported lipid bilayers and proteins using material selective nitrodopamine-mPEG.

Targeted delivery of a novel anticancer compound anisomelic acid using chitosan-coated porous silica nanorods for enhancing the apoptotic effect.

Reducible, dibromomaleimide-linked polymers for gene delivery.

Topographically grooved gel inserts for aligning epithelial cells during air-liquid-interface culture.

mRNA delivery using non-viral PCL nanoparticles.

pH and glucose responsive nanofibers for the reversible capture and release of lectins.

Dual-drug delivery of curcumin and platinum drugs in polymeric micelles enhances the synergistic effects: a double act for the treatment of multidrug-resistant cancer.

Thiol-ene immobilisation of carbohydrates onto glass slides as a simple alternative to gold-thiol monolayers, amines or lipid binding.

Overcoming tumor resistance to cisplatin through micelle-mediated combination chemotherapy.

Assembling Mn:ZnSe quantum dots-siRNA nanoplexes for gene silencing in tumor cells.

Year: 2013 Volume: 2

Dual-drug delivery of curcumin and platinum drugs in polymeric micelles enhances the synergistic effects: a double act for the treatment of multidrug-resistant cancer.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Scarano, Wei de Souza, Paul Stenzel, Martina H.
Description	Country affiliation: Australia Author Affiliation: Scarano W ( Centre for Advanced Macromolecular Design (CAMD), School of Chemistry, University of New South Wales, Sydney, NSW 2052, Australia. M.Stenzel@unsw.edu.au.)
Abstract	Combinational chemotherapy is often used to prevent drug induced resistance in cancer. The aim of this work is to test whether the co-delivery of drugs within one nanoparticle can result in increased synergistic effects of both drugs. Therefore, a micelle system with two different compartments, one for the drug curcumin and one for the conjugation of platinum drugs was designed. A triblock copolymer, based on the biodegradable polycaprolactone PCL, a PEG based shell and an amine bearing polymer as the interphase for the conjugation of platinum drugs was prepared by combination of ring-opening polymerization and RAFT polymerization. Curcumin was incorporated into the self-assembled onion-type micelle by physical encapsulation into the PCL core with an entrapment capacity of 6 wt%. The platinum(iv) drug oxoplatin was reacted with succinic anhydride to yield Pt(NH3)2Cl2[(COOH)2], which acted as the drug and as a crosslinker for the stabilisation of micelles. The size of the dual drug micelles was measured to be 38 nm by DLS, which was confirmed by TEM. The toxicity of the dual drug delivery system was tested against the A2780 human ovarian cancer cell line and compared with the IC50 value of micelles that deliver either curcumin or the platinum drug alone. The results were analysed using the CalcuSyn software. While curcumin and the platinum drug together without a carrier already showed synergy with a combination index ranging from 0.4 to 0.8, the combined delivery in one nanoparticle did enhance the synergistic effects resulting in a combination index of approximately 0.2-0.35. For comparison, a mixture of two nanoparticles, one with curcumin and the other with the platinum drug, was tested revealing a less noticeable synergistic effect compared to the co-delivery of both drugs in one drug carrier.
File Format	HTM / HTML
ISSN	20474830
Issue Number	1
Journal	Biomaterials Science
Volume Number	3
e-ISSN	20474849
Language	English
Publisher	Royal Society of Chemistry
Publisher Date	2015-01-01
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Discipline Biomedical Engineering Discipline Therapeutics
Content Type	Text
Resource Type	Article
Subject	Materials Science Biomedical Engineering

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in