NDLI: Synthesis of ROS scavenging microspheres from a dopamine containing poly(ß-amino ester) for applications for neurodegenerative disorders.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Newland, Ben Wolff, Paul Zhou, Dezhong Wang, Wei Zhang, Hong Rosser, Anne Wang, Wenxin Werner, Carsten
Description	Country affiliation: United kingdom Author Affiliation: Newland B ( Leibniz-Institut für Polymerforschung, Hohe Strasse 6, Dresden, Germany. ben@newlandresearch.net werner@ipfdd.de and Brain Repair Group, School of Biosciences, Cardiff University, Cardiff, UK.); Wolff P ( Leibniz-Institut für Polymerforschung, Hohe Strasse 6, Dresden, Germany. ben@newlandresearch.net werner@ipfdd.de.); Zhou D ( Charles Institute for Dermatology, University College Dublin, Dublin, Ireland.); Wang W ( Charles Institute for Dermatology, University College Dublin, Dublin, Ireland.); Zhang H ( Charles Institute for Dermatology, University College Dublin, Dublin, Ireland.); Rosser A ( Brain Repair Group, School of Biosciences, Cardiff University, Cardiff, UK.); Wang W ( Charles Institute for Dermatology, University College Dublin, Dublin, Ireland and School of Materials Science and Engineering, Tianjin University, Tianjin, China.); Werner C ( Leibniz-Institut für Polymerforschung, Hohe Strasse 6, Dresden, Germany. ben@newlandresearch.net werner@ipfdd.de.)
Abstract	Parkinson's disease (PD) is a common neurodegenerative disease characterized by a substantial decrease of dopaminergic neurons in the substantia nigra pars compacta. The neurological deterioration during PD can be, in part, attributed to elevated levels of reactive oxygen species (ROS). Radical scavengers have previously been shown to protect dopaminergic cells from toxic effects in vitro. Hence, new approaches need to be investigated to improve the administration of antioxidants in order to provide neuroprotection. Polymers exhibiting catechol structures offer one such approach due to their interesting physicochemical properties. In the present study a photocrosslinkable dopamine-containing poly(ß-amino ester) (DPAE) was synthesized from poly(ethylene glycol) diacrylate (PEGDA) and dopamine hydrochloride using Michael type addition. A water-in-oil emulsion technique was used to photo-crosslink the polymer into spherical microparticles. DPAE microspheres featured excellent scavenging properties towards 1,1-Diphenyl-2-picryl-hydrazyl (DPPH) radicals in a dose dependent manner and could even reduce the dissolved oxygen content of physiological solution. Furthermore, the concentrations required for radical scavenging were shown to be non-toxic towards dopaminergic SH-SY5Y cells as well as primary astrocytes and primary embryonic rat ventral midbrain cultures.
File Format	HTM / HTML
ISSN	20474830
Issue Number	3
Journal	Biomaterials Science
Volume Number	4
e-ISSN	20474849
Language	English
Publisher	Royal Society of Chemistry
Publisher Date	2016-03-01
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Discipline Biomedical Engineering Discipline Therapeutics
Content Type	Text
Resource Type	Article
Subject	Materials Science Biomedical Engineering

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