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Energy transduction: proton transfer through the respiratory complexes.
| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Hosler, Jonathan P. Ferguson-Miller, Shelagh Mills, Denise A. |
| Description | Country affiliation: United States Author Affiliation: Hosler JP ( Department of Biochemistry, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA. jhosler@biochem.umsmed.edu) |
| Abstract | A series of metalloprotein complexes embedded in a mitochondrial or bacterial membrane utilize electron transfer reactions to pump protons across the membrane and create an electrochemical potential (DeltamuH+). Current understanding of the principles of electron-driven proton transfer is discussed, mainly with respect to the wealth of knowledge available from studies of cytochrome c oxidase. Structural, experimental, and theoretical evidence supports the model of long-distance proton transfer via hydrogen-bonded water chains in proteins as well as the basic concept that proton uptake and release in a redox-driven pump are driven by charge changes at the membrane-embedded centers. Key elements in the pumping mechanism may include bound water, carboxylates, and the heme propionates, arginines, and associated water above the hemes. There is evidence for an important role of subunit III and proton backflow, but the number and nature of gating mechanisms remain elusive, as does the mechanism of physiological control of efficiency. |
| File Format | HTM / HTML |
| ISSN | 00664154 |
| e-ISSN | 15454509 |
| Journal | Annual Review of Biochemistry |
| Volume Number | 75 |
| Language | English |
| Publisher | Annual Reviews |
| Publisher Date | 2006-01-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Discipline Biochemistry Electron Transport Chain Complex Proteins Metabolism Electron Transport Complex Iv Electron Transport Physiology Oxidative Phosphorylation Protons Binding Sites Chemistry Genetics Energy Metabolism Heme Oxidation-reduction Protein Conformation Protein Subunits Static Electricity Thermodynamics Research Support, N.i.h., Extramural |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biochemistry |
