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Year: 2008 Volume: 9

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Progression in primary lateral sclerosis: a prospective analysis.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Floeter, Mary Kay Mills, Reversa
Description	Country affiliation: United States Author Affiliation: Floeter MK ( Electromyography Section, National Institutes of Neurological Disorders and Stroke, 10 Center Drive, Bethesda, Maryland 20892, USA. floeterm@ninds.nih.gov)
Abstract	OBJECTIVE: To determine whether rates and patterns of progression differ among primary lateral sclerosis (PLS) patients. METHODS: Fifty patients fulfilling clinical criteria for PLS were classified on initial presentation into three subtypes: ascending, multifocal, and sporadic paraparesis (PLS-A, PLS-M or PLS-SP). Patients were surveyed annually. Measures of movement speed, clinical rating scales, and transcranial magnetic stimulation were re-assessed at 1-5 year intervals for spread to additional body regions and progression of severity within affected regions. RESULTS: Forty-seven patients continued to fulfill criteria for PLS over a mean follow-up of 6.6 years, with a mean disease duration > 14 years. PLS-A patients had more predictable progression to additional body regions. Severity progressed faster in newly affected regions followed by stabilization in PLS-A or PLS-M subtypes. CONCLUSION: Clinical progression in PLS does not occur steadily, but has periods of faster decline upon spreading to a newly affected region. Classification of PLS patients by subtype is more relevant to predicting the spread of disease, but not progression of severity.
File Format	HTM / HTML
ISSN	21678421
e-ISSN	21679223
DOI	10.3109/17482960903171136
Journal	Amyotrophic Lateral Sclerosis
Issue Number	5-6
Volume Number	10
Language	English
Publisher	Taylor & Francis
Publisher Date	2009-10-01
Publisher Place	Great Britain (UK)
Access Restriction	Open
Subject Keyword	Discipline Neurology Disease Progression Motor Neuron Disease Age Of Onset Evoked Potentials, Motor Physiology Classification Diagnosis Physiopathology Prospective Studies Psychomotor Performance Severity Of Illness Index Research Support, N.i.h., Intramural
Content Type	Text
Resource Type	Article
Subject	Neurology Neurology (clinical)

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