NDLI: Gastroschisis: international epidemiology and public health perspectives.

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Gastroschisis: international epidemiology and public health perspectives.

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Gastroschisis: international epidemiology and public health perspectives.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Castilla, Eduardo E. Mastroiacovo, Pierpaolo Orioli, Iêda M.
Description	Country affiliation: Brazil Author Affiliation: Castilla EE ( ECLAMC/GENETICA/FIOCRUZ, Av. Brasil 4365, Pav. 26, sala 617, 21045-900 Rio de Janeiro, Brazil. castilla@centroin.com.br)
Abstract	Gastroschisis offers the intriguing epidemiological situation of a pandemic, strongly associated with very low maternal age. Identifying gastroschisis, and distinguishing it from the other abdominal wall defects, is theoretically easy but difficult in practice. The baseline birth prevalence of gastroschisis before the pandemic was approximately 1 in 50,000 births and has increased since between 10- and 20-fold. In many populations worldwide, it is still increasing. Such increasing prevalence and the association with very low maternal age are well proven, but the interaction between these two findings remains unknown. Geographic gradients (decreasing prevalence from North to South) are clear in Continental Europe and suggestive in Britain and Ireland. Gastroschisis seems more frequent in Caucasians compared to African Blacks and Orientals, and in Northern compared to Southern Europeans. These observations indicate the need for investigating gene-environment interactions. Since the global human situation is marked by inequalities among as well as within countries, the medical care and public health impact of gastroschisis varies widely among regions and social strata. The postnatal benefits of prenatal diagnosis of gastroschisis include family awareness; adequate planning of delivery with alerted obstetrical, pediatric, and surgical staff; optimal risk categorization, and personalized protocol for action. The increasing prevalence of gastroschisis combined with improved medical techniques to reduce morbidity and mortality are also increasing the burden and costs of this anomaly on health systems.
File Format	HTM / HTML
ISSN	15524868
Issue Number	3
Volume Number	148C
e-ISSN	15524876
Journal	American Journal of Medical Genetics Part C: Seminars in Medical Genetics
Language	English
Publisher	Wiley
Publisher Date	2008-08-15
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Genetics Discipline Medical Gastroschisis Epidemiology Public Health Female Geography Humans Maternal Age Prevalence Risk Factors Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Genetics Genetics (clinical)

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