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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Brummer, Grace C. Bowen, Anneli R. Bowen, Glen M. |
| Description | Country affiliation: United States Author Affiliation: Brummer GC ( University of Utah School of Medicine, 30 North 1900 East School of Medicine, Salt Lake City, UT, 84132, USA.); Bowen AR ( Department of Dermatology, University of Utah School of Medicine, 30 North 1900 East School of Medicine, 4A 330, Salt Lake City, UT, 84132, USA.); Bowen GM ( Department of Dermatology, University of Utah School of Medicine, 30 North 1900 East School of Medicine, 4A 330, Salt Lake City, UT, 84132, USA. glen.bowen@hci.utah.edu.) |
| Abstract | Merkel cell carcinoma (MCC) is a rare but aggressive cutaneous tumor with a predilection for the head and neck of elderly Caucasian patients. Although much less common than melanoma, MCC has higher rates of sentinel lymph node involvement, local and regional recurrences, and mortality. The majority of MCC cases have been linked to the relatively newly discovered Merkel cell polyomavirus, which is a ubiquitous constituent of the skin flora. Recent discoveries regarding viral integration and carcinogenesis and the immunologic features of MCC have expanded the understanding of MCC. These discoveries have led to the development and application of emerging therapies such as somatostatin analogs, immune checkpoint inhibition, adoptive cell therapy, and other exciting possibilities for targeted therapy. |
| File Format | HTM / HTML |
| ISSN | 11750561 |
| Issue Number | 1 |
| Volume Number | 17 |
| e-ISSN | 11791888 |
| Journal | American Journal of Clinical Dermatology |
| Language | English |
| Publisher | Springer |
| Publisher Date | 2016-02-01 |
| Publisher Place | New Zealand (Aotearoa) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Dermatology Carcinoma, Merkel Cell Pathology Therapy Skin Neoplasms Aged Epidemiology Cell Cycle Checkpoints Drug Effects Chemotherapy, Adjuvant Female Humans Immunotherapy, Adoptive Male Melanoma Neoplasm Recurrence, Local Neoplasm Staging Radiotherapy, Adjuvant Sentinel Lymph Node Biopsy Signal Transduction Somatostatin Analogs & Derivatives Therapeutic Use Journal Article Review |
| Content Type | Text |
| Resource Type | Article |
| Subject | Dermatology |
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