NDLI: QT Interval Prolongation and QRS Voltage Reduction in Patients with Liver Cirrhosis.

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QT Interval Prolongation and QRS Voltage Reduction in Patients with Liver Cirrhosis.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Cichoz-Lach, Halina Tomaszewski, Michal Kowalik, Agnieszka Lis, Emilia Tomaszewski, Andrzej Lach, Tomasz Boczkowska, Sylwia Celinski, Krzysztof
Description	Country affiliation: Poland Author Affiliation: Cichoz-Lach H ( Department of Gastroenterology, Medical University of Lublin, Poland.); Tomaszewski M ( Department of Cardiology, Medical University of Lublin, Poland.); Kowalik A ( Department of Gastroenterology, Medical University of Lublin, Poland.); Lis E ( Department of Gastroenterology, Medical University of Lublin, Poland.); Tomaszewski A ( Department of Cardiology, Medical University of Lublin, Poland.); Lach T ( Student of the Second Faculty of Medicine, Medical University of Lublin, Poland.); Boczkowska S ( Independent Public Clinical Hospital No. 4 in Lublin, Poland.); Celinski K ( Department of Gastroenterology, Medical University of Lublin, Poland.)
Abstract	BACKGROUND: Liver cirrhosis is associated with functional abnormalities of the cardiovascular system with co-existing electrocardiographic (ECG) abnormalities. OBJECTIVES: The aim was to analyze ECG changes in patients with cirrhosis, to evaluate whether alcoholic etiology of cirrhosis and ascites has an impact on ECG changes. MATERIAL AND METHODS: The study involved 81 patients with previously untreated alcoholic cirrhosis (64 patients with ascites, classes B and C according to the Child-Pugh classification; and 17 without ascites, categorized as class A); 41 patients with previously untreated cirrhosis due to chronic hepatitis C (HCV--30 patients with ascites, classes B and C; and 11 without ascites, class A); 42 with alcoholic steatohepatitis and 46 with alcoholic steatosis. The control group consisted of 32 healthy volunteers. Twelve-lead ECG recordings were performed and selected parameters were measured. RESULTS: Significantly longer QT and QTc intervals and lower QRS voltage were found in patients with alcoholic and HCV cirrhosis compared to the controls. Significantly lower QRS voltage was found in subjects with ascites than in those without ascites. Removal of ascites significantly increased QRS voltage. CONCLUSIONS: In cirrhosis, irrespective of etiology, ECG changes involved prolonged QT and QTc intervals and reduced QRS voltage. Prolonged QT and QTc intervals were not related to the severity of cirrhosis or to the presence of ascites. However, low QRS voltage was associated with the presence of ascites. Removal of ascites reverses low QRS voltage.
File Format	HTM / HTML
ISSN	18995276
e-ISSN	24512680
Journal	Advances in Clinical and Experimental Medicine
Issue Number	4
Volume Number	24
Language	English
Publisher	Wroclaw
Publisher Date	2015-07-01
Publisher Place	Poland
Access Restriction	Open
Subject Keyword	Discipline Medicine Arrhythmias, Cardiac Etiology Heart Conduction System Physiopathology Liver Cirrhosis Action Potentials Diagnosis Prevention & Control Ascites Therapy Electrocardiography Hepatitis, Chronic Complications Virology Liver Cirrhosis, Alcoholic Predictive Value Of Tests Prognosis Risk Factors Severity Of Illness Index Time Factors
Content Type	Text
Resource Type	Article
Subject	Reviews and References (medical) Internal Medicine Biochemistry, Genetics and Molecular Biology Pharmacology (medical) Genetics (clinical)

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