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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Diesner, Susanne C. Pali-Schöll, Isabella Jensen-Jarolim, Erika Untersmayr, Eva |
| Description | Author Affiliation: Diesner SC ( Institut für Pathophysiologie und Allergieforschung, Zentrum für Pathophysiologie, Infektiologie und Immunologie, Medizinische Universität Wien, Währinger Gürtel 18-20, E3Q, 1090, Wien, Österreich.) |
| Abstract | True food allergens are considered as digestion stable proteins, which are absorbed through the gastrointestinal epithelium in an intact form leading to sensitization and causing systemic symptoms. According to classifications, allergens, which are digestion-labile, cause local symptoms by their cross-reactivity towards inhalative allergens. Our recent studies revealed that digestion labile allergens can also have sensitizing capacity if gastric digestion is hindered. The increase of gastric pH via acid-suppression by proton pump inhibitors, sucralfate or antacids, interferes with protein digestion, and leads to sensitization and allergic reaction in mouse models as well as in human patients. Furthermore, the inhibition of digestion increases the risk for anaphylactic responses in sensitized individuals.Even though also other factors, such as sphingolipid metabolites, are associated with the development of food allergies, it is without any doubt that the stomach has an important gate keeping function against food allergies. |
| File Format | HTM / HTML |
| ISSN | 00435341 |
| Issue Number | 23-24 |
| Volume Number | 162 |
| e-ISSN | 1563258X |
| Journal | Wiener Medizinische Wochenschrift |
| Language | German |
| Publisher | Springer |
| Publisher Date | 2012-12-01 |
| Publisher Place | Austria |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Medicine Allergens Immunology Digestion Physiology Food Hypersensitivity Physiopathology Gastric Acid Hypersensitivity, Immediate Anaphylaxis Animals Antacids Administration & Dosage Adverse Effects Anti-ulcer Agents Cross Reactions Dietary Proteins Metabolism Disease Models, Animal Humans Mice Proton Pump Inhibitors Risk Factors Sphingolipids Sucralfate English Abstract Journal Article Review |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine |
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