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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Sorschag, Manfred Malle, Phillip Gallowitsch, Hans-Jürgen |
| Description | Country affiliation: Austria Author Affiliation: Sorschag M ( Department of Nuclear Medicine and Endocrinology, PET-CT Center Klagenfurt, Feschnigstraße 11, 9020 Klagenfurt, Austria. manfred.sorschag@kabeg.at) |
| Abstract | Neuroendocrine tumors (NET) are, despite increasing incidence, still rare, usually slow growing neoplasms with resemblance to nerve cells and the endocrine capability of hormone production. In contrast to commonly used conventional imaging procedures, nuclear imaging is feasible to visualize the presence of molecular biomarkers, particularly the overexpression of somatostatin receptors (sstr) with high diagnostic accuracy which has led to the establishment of somatostatin receptor scintigraphy (SRS) as essential component and gold standard of functional imaging in the workup of NET. Another major feature is the selection of patients with inoperable or metastasized tumors showing sufficient uptake for peptide receptor radionuclide therapy (PRRT). While somatostatin receptor PET and PET/CT using Ga-68-labeled SSR analogs represents the consistent further development of SRS, FDG-PET can only be used in tumors with high proliferative activity but not on a routine basis for imaging of neuroendocrine tumors. (18)F-DOPA represents an alternative PET tracer worth mentioning currently under assessment for NET imaging. |
| File Format | HTM / HTML |
| ISSN | 00435341 |
| Issue Number | 19-20 |
| Volume Number | 162 |
| e-ISSN | 1563258X |
| Journal | Wiener Medizinische Wochenschrift |
| Language | English |
| Publisher | Springer |
| Publisher Date | 2012-10-01 |
| Publisher Place | Austria |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Medicine Tumor Markers, Biological Analysis Multimodal Imaging Methods Neuroendocrine Tumors Positron-emission Tomography Radionuclide Imaging Receptors, Peptide Receptors, Somatostatin Tomography, X-ray Computed Cell Proliferation Dihydroxyphenylalanine Analogs & Derivatives Fluorodeoxyglucose F18 Gallium Radioisotopes Humans Neoplasm Staging Pathology Radiotherapy Prognosis Journal Article Review |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine |
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