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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Kronenberg, Florian Paulweber, Bernhard Lamina, Claudia |
| Description | Author Affiliation: Kronenberg F ( Division für Genetische Epidemiologie, Department für Medizinische Genetik, Molekulare and Klinische Pharmakologie, Medizinische Universität Innsbruck, Schöpfstr. 41, 6020, Innsbruck, Österreich. Florian.Kronenberg@i-med.ac.at.); Paulweber B ( Universitätsklinik für Innere Medizin I der Paracelsus Medizinischen Privatuniversität Salzburg, St. Johanns-Spital, Müllner Hauptstraße 48, 5020, Salzburg, Österreich.); Lamina C ( Division für Genetische Epidemiologie, Department für Medizinische Genetik, Molekulare and Klinische Pharmakologie, Medizinische Universität Innsbruck, Schöpfstr. 41, 6020, Innsbruck, Österreich.) |
| Abstract | The introduction of genome-wide association studies resulted in a tremendous increase in the number of genes associated with obesity and related phenotypes (BMI, waist and waist-hip-ratio). Despite this enormous gain in knowledge the search for genes is only started since only a small fraction of the heritability of these phenotypes is explained yet: each single gene of the 97 hitherto known BMI-associated genes and 49 waist-hip-ratio-associated genes explains only a tiny fraction of the variance of these phenotypes. Sex-specific differences are mainly known for waist-hip-ratio and Ì´40% of the genes showed only an effect in women but no or a markedly smaller effect in men. The functional characterization of the identified genes will take a lot of time. It is unclear whether and how fast the findings will result in therapeutic consequences. It is of utmost importance that we understand the involved mechanisms before new therapeutic strategies can be developed. |
| File Format | HTM / HTML |
| ISSN | 00435341 |
| Issue Number | 3-4 |
| Journal | Wiener Medizinische Wochenschrift |
| Volume Number | 166 |
| e-ISSN | 1563258X |
| Language | German |
| Publisher | Springer |
| Publisher Date | 2016-03-01 |
| Publisher Place | Austria |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Medicine |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine |
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