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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Kalsbeek, Andries Yi, Chun-Xia La Fleur, Susanne E. Fliers, Eric |
| Description | Country affiliation: Netherlands Author Affiliation: Kalsbeek A ( Department of Endocrinology and Metabolism, Academic Medical Center (AMC), University of Amsterdam, 1105 AZ Amsterdam, The Netherlands. a.kalsbeek@amc.uva.nl) |
| Abstract | The everyday life of mammals, including humans, exhibits many behavioral, physiological and endocrine oscillations. The major timekeeping mechanism for these rhythms is contained in the central nervous system (CNS). The output of the CNS clock not only controls daily rhythms in sleep/wake (or feeding/fasting) behavior but also exerts a direct control over glucose metabolism. Here, we show how the biological clock plays an important role in determining early morning (fasting) plasma glucose concentrations by affecting hepatic glucose production and glucose uptake, as well as glucose tolerance, by determining feeding-induced insulin responses. Recently, large-scale genetic studies in humans provided the first evidence for the involvement of disrupted (clock gene) rhythms in the pathogenesis of type 2 diabetes. |
| File Format | HTM / HTML |
| ISSN | 10432760 |
| Issue Number | 7 |
| Volume Number | 21 |
| e-ISSN | 18793061 |
| Journal | Trends in Endocrinology & Metabolism |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2010-07-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Metabolism Discipline Endocrinology Circadian Rhythm Physiology Glucose Metabolism Hypothalamus Animals Blood Glucose Glucose Tolerance Test Homeostasis Humans Liver Journal Article Research Support, Non-u.s. Gov't Review |
| Content Type | Text |
| Resource Type | Article |
| Subject | Endocrinology, Diabetes and Metabolism Endocrinology |
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