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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Griffin, M. F. Kalaskar, D. M. Seifalian, A. Butler, P. E. |
| Description | Country affiliation: United kingdom Author Affiliation: Griffin MF ( University College London, Centre for Nanotechnology & Regenerative Medicine, UCL Division of Surgery & Interventional Science, London, UK); Kalaskar DM ( University College London, Centre for Nanotechnology & Regenerative Medicine, UCL Division of Surgery & Interventional Science, London, UK); Seifalian A ( University College London, Centre for Nanotechnology & Regenerative Medicine, UCL Division of Surgery & Interventional Science, London, UK); Butler PE ( University College London, Centre for Nanotechnology & Regenerative Medicine, UCL Division of Surgery & Interventional Science, London, UK) |
| Abstract | BACKGROUND: Natural bone is a complex and hierarchical structure. Bone possesses an extracellular matrix that has a precise nano-sized environment to encourage osteoblasts to lay down bone by directing them through physical and chemical cues. For bone tissue regeneration, it is crucial for the scaffolds to mimic the native bone structure. Nanomaterials, with features on the nanoscale have shown the ability to provide the appropriate matrix environment to guide cell adhesion, migration and differentiation. METHODS: This review summarises the new developments in bone tissue engineering using nanobiomaterials. The design and selection of fabrication methods and biomaterial types for bone tissue engineering will be reviewed. The interactions of cells with different nanostructured scaffolds will be discussed including nanocomposites, nanofibres and nanoparticles. RESULTS: Several composite nanomaterials have been able to mimic the architecture of natural bone. Bioceramics biomaterials have shown to be very useful biomaterials for bone tissue engineering as they have osteoconductive and osteoinductive properties. Nanofibrous scaffolds have the ability to provide the appropriate matrix environment as they can mimic the extracellular matrix structure of bone. Nanoparticles have been used to deliver bioactive molecules and label and track stem cells. CONCLUSION: Future studies to improve the application of nanomaterials for bone tissue engineering are needed. |
| File Format | HTM / HTML |
| e-ISSN | 18743250 |
| Journal | The Open Orthopaedics Journal |
| Volume Number | 10 |
| Language | English |
| Publisher | Bentham Science Publishers |
| Publisher Date | 2016-01-01 |
| Publisher Place | Netherlands |
| Access Restriction | Open |
| Subject Keyword | Discipline Orthopedics |
| Content Type | Text |
| Resource Type | Article |
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