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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Byun, Jong-Seon Han, Yoon Hee Hong, Sung-Jun Hwang, Sung-Mi Kwon, Yong-Soo Lee, Hee Jae Kim, Sung-Soo Kim, Myong-Jo Chun, Wanjoo |
| Description | Author Affiliation: Byun JS ( Department of Pharmacology, College of Medicine, Kangwon National University, Chuncheon 200-701, Korea.) |
| Abstract | Urushinol, a plant allergen, has significantly restricted the medical application of Rhus verniciflua, although it has been reported to possess a wide variety of biological activities such as anti-inflammatory, antioxidant, and anti-cancer actions. To reduce the urushinol content while maintaining the beneficial biological activities, mushroom-mediated fermentation of Rhus verniciflua was carried out and this method resulted in significantly attenuated allergenicity [1]. In the present study, to examine the neuroprotective properties of mushroom-fermented stem bark of Rhus verniciflua, two constituents were isolated from mushroom-fermented bark and their neuroprotective properties were examined in a mouse model of kainic acid (KA)-induced excitotoxicity. KA resulted in significant apoptotic neuronal cell death in the CA3 region of mouse hippocampus. However, seven daily administrations of RVH-1 or RVH-2 prior to KA injection significantly attenuated KA-induced pyramidal neuronal cell death in the CA3 region. Furthermore, pretreatment with RVH-1 and RVH-2 also suppressed KA-induced microglial activation in the mouse hippocampus. The present study demonstrates that RVH-1 and RVH-2 isolated from Rhus verniciflua and detoxified using mushroom species possess neuroprotective properties against KA-induced excitotoxicity. This leads to the possibility that detoxified Rhus verniciflua can be a valuable asset in herbal medicine. |
| File Format | HTM / HTML |
| ISSN | 12264512 |
| e-ISSN | 20933827 |
| DOI | 10.4196/kjpp.2010.14.5.279 |
| Journal | The Korean Journal of Physiology & Pharmacology |
| Issue Number | 5 |
| Volume Number | 14 |
| Language | English |
| Publisher | Korean Physiological Society Korean Society of Pharmacology |
| Publisher Date | 2010-10-01 |
| Publisher Place | Korea (South) |
| Access Restriction | Open |
| Subject Keyword | Discipline Physiology Discipline Pharmacology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Physiology Pharmacology |
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