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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Ferraldeschi, Roberta de Bono, Johann |
| Description | Country affiliation: United kingdom Author Affiliation: Ferraldeschi R ( Institute of Cancer Research, London, United Kingdom.) |
| Abstract | In April 2011, abiraterone acetate (in combination with low-dose steroids) was approved by the US Food and Drug Administration for the treatment of men with metastatic, castration-resistant prostate cancer who have previously been treated with docetaxel-based chemotherapy. The development of abiraterone was the successful result of an improved understanding of the role of the androgen receptor signaling pathway in castration-resistant prostate cancer. Abiraterone is a rationally designed potent inhibitor of cytochrome P450, family 17, subfamily A, polypeptide 1, which is essential for synthesis of testosterone from nongonadal precursors. More recently, other drugs that act along the androgen0synthesis pathway, such as orteronel (TAK-700) and galeterone (TOK-001), have shown promise in early clinical trials. Here, we review the discovery and clinical development of abiraterone and other novel androgen-synthesis inhibitors for the management of advanced prostate cancer. |
| File Format | HTM / HTML |
| ISSN | 15289117 |
| Issue Number | 1 |
| Volume Number | 19 |
| e-ISSN | 1540336X |
| Journal | The Cancer Journal |
| Language | English |
| Publisher | Lippincott Williams & Wilkins |
| Publisher Date | 2013-01-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Oncology Androgen Antagonists Therapeutic Use Antineoplastic Agents, Hormonal Prostatic Neoplasms Drug Therapy Androstenes Androstenols Clinical Trials As Topic Drug Resistance, Neoplasm Enzyme Inhibitors Humans Male Neoplasm Staging Orchiectomy Pathology Surgery Steroid 17-alpha-hydroxylase Antagonists & Inhibitors Journal Article Review |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cancer Research Oncology |
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