NDLI: Basic mechanisms of therapeutic resistance to radiation and chemotherapy in lung cancer.

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Basic mechanisms of therapeutic resistance to radiation and chemotherapy in lung cancer.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Willers, Henning Azzoli, Christopher G. Santivasi, Wil L. Xia, Fen
Description	Country affiliation: United States Author Affiliation: Willers H ( Department of Radiation Oncology, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.)
Abstract	In recent years, there have been multiple breakthroughs in our understanding of lung cancer biology. Despite significant advances in molecular targeted therapies, DNA-damaging cytotoxic therapies will remain the mainstay of lung cancer management for the near future. Similar to the concept of personalized targeted therapies, there is mounting evidence that perturbations in DNA repair pathways are common in lung cancers, altering the resistance of the affected tumors to many chemotherapeutics as well as radiation. Defects in DNA repair may be due to a multitude of mechanisms including gene mutations, epigenetic events, and alterations in signal transduction pathways such as epidermal growth factor receptor and phosphoinositide 3-kinase/AKT. Functional biomarkers that assess the subcellular localization of central repair proteins in response to DNA damage may prove useful for individualization of cytotoxic therapies including poly(adenosine diphosphate-ribose) polymerase inhibitors. A better mechanistic understanding of cellular sensitivity and resistance to DNA damaging agents should facilitate the development of novel, individualized treatment approaches. Absolute resistance to radiation therapy, however, does not exist. To some extent, radiation therapy will always have to remain unselective and indiscriminant to eradicate persistent, drug-resistant tumor stem cell pools.
File Format	HTM / HTML
ISSN	15289117
e-ISSN	1540336X
DOI	10.1097/PPO.0b013e318292e4e3
Journal	The Cancer Journal
Issue Number	3
Volume Number	19
Language	English
Publisher	Lippincott Williams & Wilkins
Publisher Date	2013-05-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Oncology Drug Resistance, Neoplasm Lung Neoplasms Drug Therapy Radiotherapy Radiation Tolerance Animals Tumor Markers, Biological Genetics Metabolism Cell Hypoxia Cell Proliferation Dna Breaks, Double-stranded Dna Repair Pathology Tumor Burden Research Support, N.i.h., Extramural
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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