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Of microenvironments and mammary stem cells.
| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | LaBarge, Mark A. Petersen, Ole W. Bissell, Mina J. |
| Description | Country affiliation: United States Author Affiliation: LaBarge MA ( Lawrence Berkeley National Laboratory, Berkeley, CA, USA. MAlabarge@LBL.GOV) |
| Abstract | In most adult tissues there reside pools of stem and progenitor cells inside specialized microenvironments referred to as niches. The niche protects the stem cells from inappropriate expansion and directs their critical functions. Thus guided, stem cells are able to maintain tissue homeostasis throughout the ebb and flow of metabolic and physical demands encountered over a lifetime. Indeed, a pool of stem cells maintains mammary gland structure throughout development, and responds to the physiological demands associated with pregnancy. This review discusses how stem cells were identified in both human and mouse mammary glands; each requiring different techniques that were determined by differing biological needs and ethical constraints. These studies together create a robust portrait of mammary gland biology and identify the location of the stem cell niche, elucidate a developmental hierarchy, and suggest how the niche might be manipulated for therapeutic benefit. |
| File Format | HTM / HTML |
| ISSN | 15508943 |
| e-ISSN | 15586804 |
| Journal | Stem Cell Reviews and Reports |
| Issue Number | 2 |
| Volume Number | 3 |
| Language | English |
| Publisher | Springer |
| Publisher Date | 2007-06-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Discipline Cell Biology Mammary Glands, Animal Cytology Physiology Mammary Glands, Human Pregnancy Stem Cells Animals Bioethical Issues Homeostasis Mice Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Research Support, U.s. Gov't, Non-p.h.s. |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine |
