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Microstructural and functional connectivity in the developing preterm brain.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Lubsen, Julia Vohr, Betty Myers, Eliza Hampson, Michelle Lacadie, Cheryl Schneider, Karen C. Katz, Karol H. Constable, R. Todd Ment, Laura R.
Description	Country affiliation: United States Author Affiliation: Lubsen J ( Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520-8064, USA.)
Abstract	Prematurely born children are at increased risk for cognitive deficits, but the neurobiological basis of these findings remains poorly understood. Because variations in neural circuitry may influence performance on cognitive tasks, recent investigations have explored the impact of preterm birth on connectivity in the developing brain. Diffusion tensor imaging studies demonstrate widespread alterations in fractional anisotropy, a measure of axonal integrity and microstructural connectivity, throughout the developing preterm brain. Functional connectivity studies report that preterm neonates, children and adolescents exhibit alterations in both resting state and task-based connectivity when compared with term control subjects. Taken together, these data suggest that neurodevelopmental impairment following preterm birth may represent a disease of neural connectivity.
File Format	HTM / HTML
ISSN	01460005
e-ISSN	1558075X
DOI	10.1053/j.semperi.2010.10.006
Journal	Seminars in Perinatology
Issue Number	1
Volume Number	35
Language	English
Publisher	Elsevier
Publisher Date	2011-02-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Perinatology Brain Diseases Pathology Physiopathology Brain Growth & Development Infant, Premature Premature Birth Cognition Disorders Diffusion Magnetic Resonance Imaging Electrophysiological Phenomena Physiology Infant, Newborn Interneurons Magnetic Resonance Imaging Oligodendroglia Risk Factors Research Support, N.i.h., Extramural
Content Type	Text
Resource Type	Article
Subject	Pediatrics, Perinatology and Child Health Obstetrics and Gynecology

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