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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Tcherakian, C. Rivaud, E. Catherinot, E. Zucman, D. Metivier, A-C Couderc, L-J |
| Description | Country affiliation: France Author Affiliation: Tcherakian C ( Service de Pneumologie, Hôpital Foch, 40, rue Worth, 92150 Suresnes, France. c.tcherakian@hopital-foch.org) |
| Abstract | Vascular diseases have become the leading cause of mortality in the population treated for HIV infection. Pulmonary arterial hypertension (PAH) related to HIV (PAH-HIV), the fourth cause of PAH in France, has the same histological pattern as other PAH from the group 1 of Dana Point classification. But, conversely to idiopathic PAH in the general population, PAH-HIV is particular by its high frequency in HIV-infected population. This raises the question for the role of inflammation in the PAH-HIV pathophysiology. Its constant occurrence over the decades, despite introduction of combination antiretroviral therapy (CAT), does not preclude the hypothesis of an involvement of inflammation in the genesis of PAH-HIV. Indeed, it is well known that normalization of CD4+ by the CAT does not mean no inflammation. Especially, it persists an increased and continuous production of IL-6, a main cytokine in the genesis of PAH lesions. This inflammation mainly involves the endothelin-1 pathway, which has an action on endothelium and macrophages, leading to high production of IL-6. Moreover, plasmatic level of IL-6 has a prognostic value in PAH-HIV, independently from conventional (functional or hemodynamic) parameters. The use of endothelin receptor antagonist permits major effect on IL-6 production and dramatic effect on PAH in so-called 'bosentan responders'. |
| File Format | HTM / HTML |
| ISSN | 07618417 |
| Issue Number | 4 |
| Volume Number | 67 |
| Journal | Revue de Pneumologie Clinique |
| Language | French |
| Publisher | Elsevier |
| Publisher Date | 2011-09-01 |
| Publisher Place | France |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Pulmonary Medicine Hiv Infections Complications Hypertension, Pulmonary Etiology Immunology Inflammation Interleukin-6 Physiology Familial Primary Pulmonary Hypertension Drug Therapy Humans English Abstract Journal Article Review |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pulmonary and Respiratory Medicine |
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