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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Sakhri, L. Mennecier, B. Quoix, A. |
| Description | Author Affiliation: Sakhri L ( Service de pneumologie, pôle de cancérologie, médecine aiguë et communautaire, CHU Michallon, boulevard de la Chantourne, BP 217, 38043 Grenoble cedex 9, France. Electronic address: lsakhri@chu-grenoble.fr.); Mennecier B ( Service de pneumologie, nouvel hôpital civil, 1, place de l'Hôpital, BP 426, 67091 Strasbourg cedex, France.); Quoix A ( Service de pneumologie, nouvel hôpital civil, 1, place de l'Hôpital, BP 426, 67091 Strasbourg cedex, France.) |
| Abstract | Erlotinib is a tyrosine kinase inhibitor widely prescribed of which the most common sides effects are grade I or II rash and diarrhea. We report two cases of hemolytic anemia (HA) induced by erlotinib. Our two patients were treated with erlotinib after a prior line of systemic platinum-doublet therapy for metastatic non-small cell lung cancer. Both patients presented, shortly after starting treatment with erlotinib, an HA which was fatal for one of them. To our knowledge, this major side effect of erlotinib has not been reported in the literature. We will try through this article to make a literature review of the most important side effects of erlotinib and we will also focus on the HA induced by other molecules used in oncology. |
| File Format | HTM / HTML |
| ISSN | 07618417 |
| Issue Number | 6 |
| Volume Number | 69 |
| Journal | Revue de Pneumologie Clinique |
| Language | French |
| Publisher | Elsevier |
| Publisher Date | 2013-12-01 |
| Publisher Place | France |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Pulmonary Medicine Anemia, Hemolytic Chemically Induced Protein Kinase Inhibitors Adverse Effects Quinazolines Aged, 80 And Over Carcinoma, Non-small-cell Lung Drug Therapy Pathology Erlotinib Hydrochloride Humans Lung Neoplasms Male Middle Aged Therapeutic Use Case Reports English Abstract Journal Article Review |
| Content Type | Text |
| Resource Type | Case study Article |
| Subject | Pulmonary and Respiratory Medicine |
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