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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Qayyum, Abbas Ali Haack-Sørensen, Mandana Mathiasen, Anders Bruun Jørgensen, Erik Ekblond, Annette Kastrup, Jens |
| Description | Country affiliation: Denmark Author Affiliation: Qayyum AA ( Cardiac Catheterization Laboratory 2014, The Heart Centre, Rigshospitalet, Copenhagen University Hospital, 9, Blegdamsvej, DK-2100 Copenhagen Ø, Denmark.) |
| Abstract | Adipose tissue represents an abundant, accessible source of multipotent adipose-derived stromal cells (ADSCs). Animal studies have suggested that ADSCs have the potential to differentiate in vivo into endothelial cells and cardiomyocytes. This makes ADSCs a promising new cell source for regenerative therapy to replace injured tissue by creating new blood vessels and cardiomyocytes in patients with chronic ischemic heart disease. The aim of this special report is to review the present preclinical data leading to clinical stem cell therapy using ADSCs in patients with ischemic heart disease. In addition, we give an introduction to the first-in-man clinical trial, MyStromalCell Trial, which is a prospective, randomized, double-blind, placebo-controlled study using culture-expanded ADSCs obtained from adipose-derived cells from abdominal adipose tissue and stimulated with VEGF-A(165) the week before treatment. |
| File Format | HTM / HTML |
| ISSN | 17460751 |
| e-ISSN | 1746076X |
| Journal | Regenerative Medicine |
| Issue Number | 3 |
| Volume Number | 7 |
| Language | English |
| Publisher | Future Medicine Ltd. |
| Publisher Date | 2012-05-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Discipline Biotechnology Adipose Tissue Cytology Clinical Trials As Topic Mesenchymal Stem Cell Transplantation Myocardial Ischemia Therapy Research Design Animals Chronic Disease Mesenchymal Stromal Cells Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Embryology Biomedical Engineering |
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