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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Shan, Ruihui Chen, Li Li, Xinyu Wu, Hong Liang, Qingcheng Tang, Xiaobo |
| Description | Country affiliation: China Author Affiliation: Shan R ( Department of Biopharmaceutical Sciences, College of Pharmacy, Nangang District, Harbin Medical University, Harbin, China.) |
| Abstract | The initial event of hypoxic pulmonary hypertension is acute hypoxic pulmonary vasoconstriction followed by remodeling of pulmonary arteries. Although 15(S)-hydroxyeicosatetraenoic acid [15(S)-HETE] is found to be able to induce hypoxic pulmonary vasoconstriction, role of 15(S)-HETE in pulmonary artery smooth muscle cells (PASMCs) proliferation has been studied less. We sought evidence for a role of 15(S)-HETE in the development of hypoxia-induced pulmonary hypertension. We found that hypoxia enhances 15-lipoxygenase-2 (15-LOX-2) expression and stimulates cultured rabbit PASMCs proliferation. 15(S)-HETE at concentration 0.1 µM stimulated proliferation of PASMCs and induced ERK 1/ERK 2 phosphorylation but had no effect on p38 kinase expression as assessed by Western blotting. 15(S)-HETE-stimulated PASMC proliferation was blocked by the MEK inhibitors PD-98059. Hypoxia (3% O(2))-stimulated PASMC proliferation was blocked by U0126, a MEK inhibitor, as well as by NDGA and CDC, inhibitors of 15-LOX, but not by the p38 MAPK inhibitor SB-202190. We conclude that 15-LOX-2 and its product, 15(S)-HETE, are important intermediates in hypoxia-induced rabbit PASMC proliferation and may participate in hypoxia-induced pulmonary hypertension. |
| File Format | HTM / HTML |
| ISSN | 09523278 |
| Issue Number | 1-2 |
| Volume Number | 86 |
| e-ISSN | 15322823 |
| Journal | Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2012-01-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Endocrinology Arachidonate 15-lipoxygenase Metabolism Cell Proliferation Hydroxyeicosatetraenoic Acids Myocytes, Smooth Muscle Animals Animals, Newborn Blotting, Western Butadienes Pharmacology Caffeic Acids Cell Survival Drug Effects Cells, Cultured Flavonoids Physiology Anoxia Lipoxygenase Inhibitors Masoprocol Mitogen-activated Protein Kinase 1 Antagonists & Inhibitors Mitogen-activated Protein Kinase 3 Muscle, Smooth, Vascular Cytology Nitriles Pulmonary Artery Rabbits Time Factors Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Clinical Biochemistry |
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