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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Reese, Edmund A. Cheon, Yewon Ramadan, Epolia Kim, Hyung-Wook Chang, Lisa Rao, Jagadeesh S. Rapoport, Stanley I. Taha, Ameer Y. |
| Description | Country affiliation: United States Author Affiliation: Reese EA ( Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.) |
| Abstract | In rats, FDA-approved mood stabilizers used for treating bipolar disorder (BD) selectively downregulate brain markers of the arachidonic acid (AA) cascade, which are upregulated in postmortem BD brain. Phase III clinical trials show that gabapentin (GBP) is ineffective in treating BD. We hypothesized that GBP would not alter the rat brain AA cascade. Chronic GBP (10 mg/kg body weight, injected i.p. for 30 days) compared to saline vehicle did not significantly alter brain expression or activity of AA-selective cytosolic phospholipase $A_{2}$ $(cPLA_{2})$ IVA or secretory (s) $PLA_{2}$ IIA, activity of cyclooxygenase-2, or prostaglandin or thromboxane concentrations. Plasma AA concentration was unaffected. These results, taken with evidence of an upregulated AA cascade in the BD brain and that approved mood stabilizers downregulate rat brain AA cascade, support the hypothesis that effective anti-BD drugs act by targeting the AA cascade, and suggest that the rat model might be used for drug screening |
| File Format | HTM / HTML |
| ISSN | 09523278 |
| e-ISSN | 15322823 |
| DOI | 10.1016/j.plefa.2012.06.003 |
| Journal | Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) |
| Issue Number | 2-3 |
| Volume Number | 87 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2012-08-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Discipline Endocrinology Amines Pharmacology Anti-anxiety Agents Arachidonic Acid Metabolism Bipolar Disorder Brain Cyclohexanecarboxylic Acids Gamma-aminobutyric Acid Animals Biological Markers Blood Drug Therapy Drug Effects Enzymology Cyclooxygenase 1 Genetics Cyclooxygenase 2 Dinoprostone Drug Evaluation, Preclinical Fatty Acids Fructose Analogs & Derivatives Gene Expression Group Vi Phospholipases A2 Membrane Proteins Phospholipases A2, Cytosolic Phospholipases A2, Secretory Rats, Inbred F344 Thromboxane B2 Research Support, N.i.h., Intramural |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Clinical Biochemistry |
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