NDLI: Association of polyunsaturated fatty acids in breast milk with fatty acid desaturase gene polymorphisms among Chinese lactating mothers.

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Association of polyunsaturated fatty acids in breast milk with fatty acid desaturase gene polymorphisms among Chinese lactating mothers.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Ding, Zhen Liu, Guo-Liang Li, Xiang Chen, Xue-Yan Wu, Yi-Xia Cui, Can-Can Zhang, Xi Yang, Guang Xie, Lin
Description	Country affiliation: China Author Affiliation: Ding Z ( Department of Nutrition and Food Hygiene, School of Public Health, Jilin University, Chang Chun 130021, China.); Liu GL ( Experimental Center of Prevention, School of Public Health, Jilin University, Chang Chun 130021, China.); Li X ( Department of Nutrition and Food Hygiene, School of Public Health, Jilin University, Chang Chun 130021, China.); Chen XY ( Department of Nutrition and Food Hygiene, School of Public Health, Jilin University, Chang Chun 130021, China.); Wu YX ( Department of Nutrition and Food Hygiene, School of Public Health, Jilin University, Chang Chun 130021, China.); Cui CC ( Medical Law, the Grade of 2011, School of Public Health, Jilin University, Chang Chun 130021, China.); Zhang X ( Medical Law, the Grade of 2011, School of Public Health, Jilin University, Chang Chun 130021, China.); Yang G ( Medical Law, the Grade of 2011, School of Public Health, Jilin University, Chang Chun 130021, China.); Xie L ( Department of Nutrition and Food Hygiene, School of Public Health, Jilin University, Chang Chun 130021, China. Electronic address: xielin@jlu.edu.cn.)
Abstract	BACKGROUND: The fatty acid desaturase (FADS) controls polyunsaturated fatty acid (PUFA) synthesis in human tissues and breast milk. DESIGN: Evaluate the influence of 10 single nucleotide polymorphisms (SNPs) and various haplotypes in the FADS gene cluster (FADS1, FADS2, FADS3) on PUFA concentration in the breast milk of 209 healthy Chinese women. PUFA concentrations were measured in breast milk using gas chromatography and genotyping was performed using the Sequenom Mass Array system. RESULTS: A SNP (rs1535) and 2-locus haplotypes (rs3834458-rs1535, rs1535-rs174575) in the FADS2 gene were associated with concentrations of Î³-linoleic acid (GLA) and arachidonic acid (AA) in breast milk. Likewise, in the FADS1 gene, a 2-locus constructed haplotype (rs174547-rs174553) also affected GLA and AA concentration (P<0.05 for all). Minor allele carriers of the SNP and haplotypes described above had lower concentrations of GLA and AA. In the FADS2 gene, the 3-locus haplotype rs3834458-rs1535-rs174575, significantly affected concentrations of GLA but not AA. Pairwise comparison showed that individuals major homozygous for the SNP rs1000778 in the FADS3 gene had lower concentrations of ALA and linoleic acid (LA) in their breast milk. CONCLUSION: Polymorphisms in the FADS gene cluster influence PUFA concentrations in the breast milk of Chinese Han lactating women.
File Format	HTM / HTML
ISSN	09523278
Journal	Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA)
Volume Number	109
e-ISSN	15322823
Language	English
Publisher	Elsevier
Publisher Date	2016-06-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Endocrinology
Content Type	Text
Resource Type	Article
Subject	Cell Biology Clinical Biochemistry

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