NDLI: Metabolism of brain cortex and cardiac muscle mitochondria in hibernating 13-lined ground squirrels Ictidomys tridecemlineatus.

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Metabolism of brain cortex and cardiac muscle mitochondria in hibernating 13-lined ground squirrels Ictidomys tridecemlineatus.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Gallagher, Kirsten Staples, James F.
Spatial Coverage	Manitoba
Description	Country affiliation: Canada Author Affiliation: Gallagher K ( Department of Biology, University of Western Ontario, London, Ontario N6A 5B7, Canada.)
Abstract	During bouts of torpor, mitochondrial metabolism is known to be suppressed in the liver and skeletal muscle of hibernating mammals. This suppression is rapidly reversed during interbout euthermic (IBE) phases, when whole-animal metabolic rate and body temperature (T(b)) return spontaneously to euthermic levels. Such mitochondrial suppression may contribute significantly to energy savings, but the capacity of other tissues to suppress mitochondrial metabolism remains unclear. In this study we compared the metabolism of mitochondria from brain cortex and left ventricular cardiac muscle between animals sampled while torpid (stable T(b) near 5°C) and in IBE (stable T(b) near 37°C). Instead of isolating mitochondria using the traditional methods of homogenization and centrifugation, we permeabilized tissue slices with saponin, allowing energetic substrates and inhibitors to access mitochondria. No significant differences in state 3 or state 4 respiration were observed between torpor and IBE in either tissue. In general, succinate produced the highest oxidation rates followed by pyruvate and then glutamate, palmitoyl carnitine, and ß-hydroxybutyrate. These findings suggest that there is no suppression of mitochondrial metabolism or change in substrate preference in these two tissues despite the large changes in whole-animal metabolism seen between torpor and IBE.
File Format	HTM / HTML
ISSN	15222152
Issue Number	1
Volume Number	86
e-ISSN	15375293
Journal	Physiological and Biochemical Zoology
Language	English
Publisher	University of Chicago Press
Publisher Date	2013-01-01
Publisher Place	United States
Access Restriction	Subscribed
Subject Keyword	Discipline Physiology Discipline Biochemistry Discipline Zoology Cerebral Cortex Metabolism Hibernation Mitochondria Myocardium Reactive Oxygen Species Sciuridae Physiology Animals Cell Respiration Heart Ventricles Manitoba Mitochondria, Muscle Saponins Seasons Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Physiology Biochemistry Animal Science and Zoology

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Substrate-specific changes in mitochondrial respiration in skeletal and cardiac muscle of hibernating thirteen-lined ground squirrels.

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Progestogen metabolites for use in pregnancy monitoring of 13-lined ground squirrels (Ictidomys tridecemlineatus)

Metabolism of brain cortex and cardiac muscle mitochondria in hibernating 13-lined ground squirrels Ictidomys tridecemlineatus.

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