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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Yashin, A. I. Arbeev, K. G. Akushevich, I. Kulminski, A. Ukraintseva, S. V. Stallard, E. Land, K. C. |
| Description | Country affiliation: United States Author Affiliation: Yashin AI ( Center for Population Health and Aging, Duke University, Durham, NC 27708, United States. aiy@duke.edu) |
| Abstract | A better understanding of processes and mechanisms linking human aging with changes in health status and survival requires methods capable of analyzing new data that take into account knowledge about these processes accumulated in the field. In this paper, we describe an approach to analyses of longitudinal data based on the use of stochastic process models of human aging, health, and longevity which allows for incorporating state of the art advances in aging research into the model structure. In particular, the model incorporates the notions of resistance to stresses, adaptive capacity, and 'optimal' (normal) physiological states. To capture the effects of exposure to persistent external disturbances, the notions of allostatic adaptation and allostatic load are introduced. These notions facilitate the description and explanation of deviations of individuals' physiological indices from their normal states, which increase the chances of disease development and death. The model provides a convenient conceptual framework for comprehensive systemic analyses of aging-related changes in humans using longitudinal data and linking these changes with genotyping profiles, morbidity, and mortality risks. The model is used for developing new statistical methods for analyzing longitudinal data on aging, health, and longevity. |
| File Format | HTM / HTML |
| ISSN | 15710645 |
| e-ISSN | 18731457 |
| DOI | 10.1016/j.plrev.2012.05.002 |
| Journal | Physics of Life Reviews |
| Issue Number | 2 |
| Volume Number | 9 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2012-06-01 |
| Publisher Place | Netherlands |
| Access Restriction | Open |
| Subject Keyword | Discipline Physics Discipline Biophysics Aging Life Expectancy Longevity Longitudinal Studies Statistics & Numerical Data Proportional Hazards Models Research Support, N.i.h., Extramural |
| Content Type | Text |
| Resource Type | Article |
| Subject | Artificial Intelligence Physics and Astronomy Agricultural and Biological Sciences |
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