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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Colomb, Warren Sarkar, Susanta K. |
| Description | Country affiliation: United States Author Affiliation: Colomb W ( Department of Physics, Colorado School of Mines, Golden, CO 80401, United States.); Sarkar SK ( Department of Physics, Colorado School of Mines, Golden, CO 80401, United States. Electronic address: ssarkar@mines.edu.) |
| Abstract | Studying individual biomolecules at the single-molecule level has proved very insightful recently. Single-molecule experiments allow us to probe both the equilibrium and nonequilibrium properties as well as make quantitative connections with ensemble experiments and equilibrium thermodynamics. However, it is important to be careful about the analysis of single-molecule data because of the noise present and the lack of theoretical framework for processes far away from equilibrium. Biomolecular motion, whether it is free in solution, on a substrate, or under force, involves thermal fluctuations in varying degrees, which makes the motion noisy. In addition, the noise from the experimental setup makes it even more complex. The details of biologically relevant interactions, conformational dynamics, and activities are hidden in the noisy single-molecule data. As such, extracting biological insights from noisy data is still an active area of research. In this review, we will focus on analyzing both fluorescence-based and force-based single-molecule experiments and gaining biological insights at the single-molecule level. Inherently nonequilibrium nature of biological processes will be highlighted. Simulated trajectories of biomolecular diffusion will be used to compare and validate various analysis techniques. |
| File Format | HTM / HTML |
| ISSN | 15710645 |
| Volume Number | 13 |
| e-ISSN | 18731457 |
| Journal | Physics of Life Reviews |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-06-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Physics Discipline Biophysics Fluorescence Resonance Energy Transfer Methods Nanotechnology Physics Single-cell Analysis Animals Fluorescence Humans Thermodynamics Journal Article Research Support, Non-u.s. Gov't Review |
| Content Type | Text |
| Resource Type | Article |
| Subject | Artificial Intelligence Physics and Astronomy Agricultural and Biological Sciences |
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