NDLI: Optimal light dose and drug dosage in the photodynamic treatment using PHOTOCYANINE.

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Optimal light dose and drug dosage in the photodynamic treatment using PHOTOCYANINE.

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Optimal light dose and drug dosage in the photodynamic treatment using PHOTOCYANINE.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Xue, Jinping Li, Chao Liu, Hong Wei, Jinfeng Chen, Naisheng Huang, Jinling
Description	Author Affiliation: Xue J ( Institute of Research on Functional Materials, College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou 350002, PR China. xuejinping66@yahoo.com.cn)
Abstract	BACKGROUND: To explore the effective dose range of PHOTOCYANINE, the intensity and duration of irradiation using a 670-nm laser, and changes of local tissues after photodynamic therapy (PDT) in mice with S180 tumors to provide evidence for the clinical application of PDT. BASIC METHODS: Kunming mice were administered the photosensitizer PHOTOCYANINE. After the administration of PHOTOCYANINE, irradiation with 670-nm laser had a remarkable inhibitory effect on the growth of the grafted tumor S180. MAIN RESULTS: Within the power densities 36-144J/cm(2), the irradiation dose showed a significant dose-response relationship; under the same drug dosage, an increase in irradiation dose could enhance the inhibitory effect on tumor growth. In the groups administered PHOTOCYANINE and irradiated with a 670-nm laser, the temperature of the local surface did not increase remarkably, an effect also seen in the negative control group. Local swelling around the tumor occurred immediately after PHOTOCYANINE administration and laser irradiation, and could last for about 3 days. Vertical resection of the tumors 72 h after irradiation showed that the depth of local-tissue necrosis after PHOTOCYANINE administration and laser irradiation was 5.7-7.5mm. PRINCIPAL CONCLUSIONS: The efficacy of PHOTOCYANINE was significantly correlated with its dose; under identical irradiation conditions, the increase in drug dose increased the tumor inhibition rate (TIR) within a certain dose range. The efficacy of PHOTOCYANINE also showed significant irradiation-dependent characteristics.
File Format	HTM / HTML
ISSN	15721000
Issue Number	3
Volume Number	8
e-ISSN	18731597
Journal	Photodiagnosis and Photodynamic Therapy
Language	English
Publisher	Elsevier
Publisher Date	2011-09-01
Publisher Place	Netherlands
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Diagnostic Imaging Discipline Therapeutics Antineoplastic Agents Administration & Dosage Indoles Organometallic Compounds Photochemotherapy Methods Photosensitizing Agents Radiation Dosage Sarcoma, Experimental Drug Therapy Zinc Animals Body Temperature Drug Effects Radiation Effects Body Weight Dose-response Relationship, Drug Dose-response Relationship, Radiation Lasers Mice Necrosis Random Allocation Pathology Skin Neoplasms Time Factors Tumor Burden Comparative Study Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Biophysics Dermatology Pharmacology (medical) Oncology

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